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International Journal of Inflammation
Volume 2012 (2012), Article ID 173675, 8 pages
http://dx.doi.org/10.1155/2012/173675
Review Article

Protective Effect of Melatonin on Acute Pancreatitis

Department of Medical Physiology, Faculty of Health Sciences, Jagiellonian University, Medical College, Michalowskiego 12, 31-126, Krakow, Poland

Received 25 November 2011; Revised 22 January 2012; Accepted 2 February 2012

Academic Editor: Zoltan Rakonczay

Copyright © 2012 Jolanta Jaworek et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Linked References

  1. A. B. Lerner, J. D. Case, Y. Takahashi, T. H. Lee, and W. Mori, “Isolation of melatonin, the pineal gland factor that lightens melanocytes,” Journal of the American Chemical Society, vol. 80, no. 10, p. 2587, 1958. View at Google Scholar · View at Scopus
  2. B. Berra and A. M. Rizzo, “Melatonin: circadian rhythm regulator, chronobiotic, antioxidant and beyond,” Clinics in Dermatology, vol. 27, no. 2, pp. 202–209, 2009. View at Publisher · View at Google Scholar · View at Scopus
  3. S. Esteban, C. Garau, S. Aparicio et al., “Chronic melatonin treatment and its precursor L-tryptophan improve the monoaminergic neurotransmission and related behavior in the aged rat brain,” Journal of Pineal Research, vol. 48, no. 2, pp. 170–177, 2010. View at Publisher · View at Google Scholar · View at Scopus
  4. J. B. Zawilska, D. J. Skene, and J. Arendt, “Physiology and pharmacology of melatonin in relation to biological rhythms,” Pharmacological Reports, vol. 61, no. 3, pp. 383–410, 2009. View at Google Scholar · View at Scopus
  5. G. A. Bubenik, “Thirty four years since the discovery of gastrointestinal melatonin,” Journal of Physiology and Pharmacology, vol. 59, no. 2, supplement, pp. 33–51, 2008. View at Google Scholar
  6. C.-Q. Chen, J. Fichna, M. Bashashati, Y.-Y. Li, and M. Storr, “Distribution, function and physiological role of melatonin in the lower gut,” World Journal of Gastroenterology, vol. 17, no. 34, pp. 3888–3898, 2011. View at Publisher · View at Google Scholar
  7. G. A. Bubenik, S. F. Pang, R. R. Hacker, and P. S. Smith, “Melatonin concentrations in serum and tissues of porcine gastrointestinal tract and their relationship to the intake and passage of food,” Journal of Pineal Research, vol. 21, no. 4, pp. 251–256, 1996. View at Google Scholar · View at Scopus
  8. J. Stefulj, M. Hörtner, M. Ghosh et al., “Gene expression of the key enzymes of melatonin synthesis in extrapineal tissues of the rat,” Journal of Pineal Research, vol. 30, no. 4, pp. 243–247, 2001. View at Publisher · View at Google Scholar
  9. M. Shimozuma, R. Tokuyama, S. Tatehara et al., “Expression and cellular localization of melatonin-synthesis enzyme in rat and human salivary glands,” Histochemistry and Cell Biology, vol. 135, no. 4, pp. 389–396, 2011. View at Google Scholar
  10. G. Huether, B. Poeggeler, A. Reimer, and A. George, “Effect of tryptophan administration on circulating melatonin levels in chicks and rats: evidence for stimulation of melatonin synthesis and release in the gastrointestinal tract,” Life Sciences, vol. 51, no. 12, pp. 945–953, 1992. View at Google Scholar · View at Scopus
  11. N. T. Raikhlin, I. M. Kvetnoy, and V. N. Tolkachev, “Melatonin may be synthesised in enterochromaffin cells,” Nature, vol. 255, no. 5506, pp. 344–345, 1975. View at Google Scholar · View at Scopus
  12. I. M. Kvetnoy, I. E. Ingel, T. V. Kvetnaia et al., “Gastrointestinal melatonin: cellular identification and biological role,” Neuroendocrinology Letters, vol. 23, no. 2, pp. 121–132, 2002. View at Google Scholar
  13. D. X. Tan, L. C. Manchester, R. J. Reiter, W. Qi, M. A. Hanes, and N. J. Farley, “High physiological levels of melatonin in the bile of mammals,” Life Sciences, vol. 65, no. 23, pp. 2523–2529, 1999. View at Publisher · View at Google Scholar · View at Scopus
  14. M. Messner, G. Huether, T. Lorf, G. Ramadori, and H. Schwörer, “Presence of melatonin in the human hepatobiliary-gastrointestinal tract,” Life Sciences, vol. 69, no. 5, pp. 543–551, 2001. View at Publisher · View at Google Scholar · View at Scopus
  15. G. A. Bubenik and G. M. Brown, “Pinealectomy reduces melatonin levels in the serum but not in the gastrointestinial tract of rats,” Biological Signals, vol. 6, no. 1, pp. 40–44, 1997. View at Google Scholar · View at Scopus
  16. J. Jaworek, A. Leja-Szpak, J. Bonior et al., “Protective effect of melatonin and its precursor L-tryptophan on acute pancreatitis induced by caerulein overstimulation or ischemia/reperfusion,” Journal of Pineal Research, vol. 34, no. 1, pp. 40–52, 2003. View at Publisher · View at Google Scholar · View at Scopus
  17. J. Jaworek, K. Nawrot-Porabka, A. Leja-Szpak et al., “Melatonin as modulator of pancreatic enzyme secretion and pancreatoprotector,” Journal of Physiology and Pharmacology, vol. 58, no. 6, supplement, pp. 65–80, 2007. View at Google Scholar
  18. K. Stebelová, K. Anttila, S. Mänttäri, S. Saarela, and M. Zeman, “Immunohistochemical definition of MT2 receptors and melatonin in the gastrointestinal tissues of rat,” Acta Histochemica, vol. 112, no. 1, pp. 26–33, 2010. View at Publisher · View at Google Scholar
  19. K. Stebelová, I. Herichová, and M. Zeman, “Diabetes induces changes in melatonin concentrations in peripheral tissues of rat,” Neuroendocrinology Letters, vol. 28, no. 2, pp. 159–165, 2007. View at Google Scholar
  20. R. D. Ramracheya, D. S. Muller, P. E. Squires et al., “Function and expression of melatonin receptors on human pancreatic islets,” Journal of Pineal Research, vol. 44, no. 3, pp. 273–279, 2008. View at Publisher · View at Google Scholar · View at Scopus
  21. E. Peschke, I. Stumpf, I. Bazwinsky, L. Litvak, H. Dralle, and E. Mühlbauer, “Melatonin and type 2 diabetes—a possible link?” Journal of Pineal Research, vol. 42, no. 4, pp. 350–358, 2007. View at Publisher · View at Google Scholar · View at Scopus
  22. C. Langenberg, L. Pascoe, A. Mari et al., “Common genetic variation in the melatonin receptor 1B gene (MTNR1B) is associated with decreased early-phase insulin response,” Diabetologia, vol. 52, no. 8, pp. 1537–1542, 2009. View at Publisher · View at Google Scholar · View at Scopus
  23. M. C. Picinato, A. E. Hirata, J. Cipolla-Neto et al., “Activation of insulin and IGF-1 signaling pathways by melatonin through MT1 receptor in isolated rat pancreatic islets,” Journal of Pineal Research, vol. 44, no. 1, pp. 88–94, 2008. View at Publisher · View at Google Scholar · View at Scopus
  24. H. Mulder, C. L. F. Nagorny, V. Lyssenko, and L. Groop, “Melatonin receptors in pancreatic islets: good morning to a novel type 2 diabetes gene,” Diabetologia, vol. 52, no. 7, pp. 1240–1249, 2009. View at Publisher · View at Google Scholar · View at Scopus
  25. J. Jaworek, K. Nawrot, S. J. Konturek, A. Leja-Szpak, P. Thor, and W. W. Pawlik, “Melatonin and its precursor, L-tryptophan: influence on pancreatic amylase secretion in vivo and in vitro,” Journal of Pineal Research, vol. 36, no. 3, pp. 155–164, 2004. View at Google Scholar · View at Scopus
  26. A. Leja-Szpak, J. Jaworek, K. Nawrot-Porabka et al., “Modulation of pancreatic enzyme secretion by melatonin and its precursor; L-tryptophan. Role of CCK and afferent nerves,” Journal of Physiology and Pharmacology, vol. 55, pp. 33–46, 2004. View at Google Scholar · View at Scopus
  27. T. L. Sletten, S. Vincenzi, J. R. Redman, S. W. Lockley, and S. M. Rajaratnam, “Timing of sleep and its relationship with the endogenous melatonin rhythm,” Frontiers in Neurology, vol. 1, pp. 137–147, 2010. View at Google Scholar
  28. C. Chojnacki, M. Wisniewska-Jarosińska, E. Walecka-Kapica, G. Klupińska, J. Jaworek, and J. Chojnacki, “Evaluation of melatonin effectiveness in the adjuvant treatment of ulcerative colitis,” Journal of Physiology and Pharmacology, vol. 62, no. 3, pp. 327–334, 2011. View at Google Scholar
  29. J. J. Ochoa, J. Díaz-Castro, N. Kajarabille et al., “Melatonin supplementation ameliorates oxidative stress and inflammatory signaling induced by strenuous exercise in adult human males,” Journal of Pineal Research, vol. 51, no. 4, pp. 373–380, 2011. View at Publisher · View at Google Scholar
  30. Z. Kurcer, E. Oguz, H. Ozbilge et al., “Melatonin protects from ischemia/reperfusion-induced renal injury in rats: this effect is not mediated by proinflammatory cytokines,” Journal of Pineal Research, vol. 43, no. 2, pp. 172–178, 2007. View at Publisher · View at Google Scholar · View at Scopus
  31. M. I. Rodríguez, G. Escames, L. C. López et al., “Chronic melatonin treatment reduces the age-dependent inflammatory process in senescence-accelerated mice,” Journal of Pineal Research, vol. 42, no. 3, pp. 272–279, 2007. View at Publisher · View at Google Scholar
  32. K. Ganguly, A. V. Sharma, R. J. Reiter, and S. Swarnakar, “Melatonin promotes angiogenesis during protection and healing of indomethacin-induced gastric ulcer: role of matrix metaloproteinase-2,” Journal of Pineal Research, vol. 49, no. 2, pp. 130–140, 2010. View at Publisher · View at Google Scholar · View at Scopus
  33. S. J. Konturek, P. C. Konturek, T. Brzozowki, and G. Bubenik, “Role of melatonin in the upper gastrointestinal tract,” Journal of Physiology and Pharmacology, vol. 58, no. 6, supplement, pp. 23–52, 2007. View at Google Scholar
  34. S. C. Miller, P. S. R. Pandi, A. I. Esquifino, D. P. Cardinali, and G. J. M. Maestroni, “The role of melatonin in immuno-enhancement: potential application in cancer,” International Journal of Experimental Pathology, vol. 87, no. 2, pp. 81–87, 2006. View at Publisher · View at Google Scholar · View at Scopus
  35. A. Carrillo-Vico, R. J. Reiter, P. J. Lardone et al., “The modulatory role of melatonin on immune responsiveness,” Current Opinion in Investigational Drugs, vol. 7, no. 5, pp. 423–431, 2006. View at Google Scholar · View at Scopus
  36. S. D. Paredes, S. Sánchez, H. Parvez, A. B. Rodríguez, and C. Barriga, “Altered circadian rhythms of corticosterone, melatonin, and phagocytic activity in response to stress in rats,” Neuroendocrinology Letters, vol. 28, no. 4, pp. 489–495, 2007. View at Google Scholar
  37. F. L. Yang, Y. M. Subeq, C. J. Lee, R. P. Lee, T. C. Peng, and B. G. Hsu, “Melatonin Ameliorates Hemorrhagic Shock-Induced Organ Damage in Rats,” Journal of Surgical Research, vol. 167, no. 3, pp. 15–21, 2011. View at Publisher · View at Google Scholar · View at Scopus
  38. M. P. Terron, J. Delgado, S. D. Paredes, C. Barriga, R. J. Reiter, and A. B. Rodroguez, “Effect of melatonin and L-tryptophan on humoral immunity in young and old ringdoves (Streptopelia risoria),” Experimental Gerontology, vol. 44, no. 10, pp. 653–658, 2009. View at Google Scholar
  39. W. Zhou, P. Wang, and L. Tao, “Effect of melatonin on proliferation of neonatal cord blood mononuclear cells,” World Journal of Pediatrics, vol. 5, no. 4, pp. 300–303, 2009. View at Publisher · View at Google Scholar · View at Scopus
  40. D. Mukherjee, S. G. Roy, A. Bandyopadhyay et al., “Melatonin protects against isoproterenol-induced myocardial injury in the rat: antioxidative mechanisms,” Journal of Pineal Research, vol. 48, no. 3, pp. 251–262, 2010. View at Publisher · View at Google Scholar · View at Scopus
  41. G. J. Lin, S. H. Huang, Y. W. Chen et al., “Melatonin prolongs islet graft survival in diabetic NOD mice,” Journal of Pineal Research, vol. 47, no. 3, pp. 284–292, 2009. View at Publisher · View at Google Scholar · View at Scopus
  42. S. Lahiri, P. Singh, S. Singh, N. Rasheed, G. Palit, and K. K. Pant, “Melatonin protects against experimental reflux esophagitis,” Journal of Pineal Research, vol. 46, no. 2, pp. 207–213, 2009. View at Publisher · View at Google Scholar · View at Scopus
  43. E. Miller, M. Mrowicka, K. Malinowska, J. Kędziora, and I. Majsterek, “The effect of whole body cryotherapy and melatonin supplementation on total antioxidative status and some antioxidative enzyme in multiple sclerosis patients,” Polski Merkuriusz Lekarski, vol. 31, no. 183, pp. 150–153, 2011. View at Google Scholar
  44. K. Shagirtha, M. Muthumani, and S. Milton Prabu, “Melatonin abrogates cadmium induced oxidative stress related neurotoxicity in rats,” European Review for Medical and Pharmacological Sciences, vol. 15, no. 9, pp. 1039–1050, 2011. View at Google Scholar
  45. D. X. Tan, L. C. Manchester, M. P. Terron, L. J. Flores, and R. J. Reiter, “One molecule, many derivatives: a never-ending interaction of melatonin with reactive oxygen and nitrogen species?” Journal of Pineal Research, vol. 42, no. 1, pp. 28–42, 2007. View at Publisher · View at Google Scholar · View at Scopus
  46. F. Peyrot and C. Ducrocq, “Potential role of tryptophan derivatives in stress responses characterized by the generation of reactive oxygen and nitrogen species,” Journal of Pineal Research, vol. 45, no. 3, pp. 235–246, 2008. View at Publisher · View at Google Scholar · View at Scopus
  47. R. J. Reiter, S. D. Paredes, A. Korkmaz, J. Joum, and D. X. Tan, “Melatonin combats molecular terrorism at the mitochondrial level,” Interdisciplinary Toxicology, vol. 1, pp. 137–148, 2008. View at Google Scholar
  48. F. Martínez-Cruz, C. Osuna, and J. M. Guerrero, “Mitochondrial damage induced by fetal hyperphenylalaninemia in the rat brain and liver: its prevention by melatonin, Vitamin E, and Vitamin C,” Neuroscience Letters, vol. 392, no. 1-2, pp. 1–4, 2006. View at Publisher · View at Google Scholar · View at Scopus
  49. P. Durante, F. Romero, M. Pérez, M. Chávez, and G. Parra, “Effect of uric acid on nephrotoxicity induced by mercuric chloride in rats,” Toxicology and Industrial Health, vol. 26, no. 3, pp. 163–174, 2010. View at Publisher · View at Google Scholar · View at Scopus
  50. C. M. BergaminiI, S. Gambetti, A. Dondi, and C. Cervellaci, “Oxygen reactive species and tissue damage,” Current Pharmaceutical Design, vol. 10, pp. 1611–1626, 2004. View at Google Scholar
  51. E. Gałecka, M. Mrowicka, K. Malinowska, and P. Gałecki, “Role of free radicals in the physiological processes,” Polski Merkuriusz Lekarski, vol. 24, no. 143, pp. 446–448, 2008. View at Google Scholar · View at Scopus
  52. V. Afonso, R. Champy, D. Mitrovic, P. Collin, and A. Lomri, “Reactive oxygen species and superoxide dismutases: role in joint diseases,” Joint Bone Spine, vol. 74, no. 4, pp. 324–329, 2007. View at Publisher · View at Google Scholar · View at Scopus
  53. C. Shi, R. Andersson, X. Zhao, and X. Wang, “Potential role of reactive oxygen species in pancreatitis-associated multiple organ dysfunction,” Pancreatology, vol. 5, no. 4-5, pp. 492–500, 2005. View at Publisher · View at Google Scholar · View at Scopus
  54. B. Modzelewski and A. Janiak, “Lipid peroxidation product as prognostic factors in acute necrotizing pancreatitis,” Polski Merkuriusz Lekarski, vol. 19, no. 112, pp. 511–513, 2005. View at Google Scholar · View at Scopus
  55. R. J. Reiter, D. X. Tan, L. C. Manchester, M. Pilar Terron, L. J. Flores, and S. Koppisepi, “Medical implications of melatonin: receptor-mediated and receptor-independent actions,” Advances in medical sciences, vol. 52, pp. 11–28, 2007. View at Google Scholar · View at Scopus
  56. K. H. Jung, S. W. Hong, H. M. Zheng et al., “Melatonin ameliorates cerulein-induced pancreatitis by the modulation of nuclear erythroid 2-related factor 2 and nuclear factor-kappaB in rats,” Journal of Pineal Research, vol. 48, no. 3, pp. 239–250, 2010. View at Publisher · View at Google Scholar · View at Scopus
  57. X. F. Sun and H. Zhang, “NFKB and NFKBI polymorphisms in relation to susceptibility of tumour and other diseases,” Histology and Histopathology, vol. 22, no. 12, pp. 1387–1398, 2007. View at Google Scholar
  58. M. Czyz, “Specificity and selectivity of the NFkappaB response,” Postepy Biochemii, vol. 51, no. 1, pp. 60–68, 2005. View at Google Scholar · View at Scopus
  59. H. M. Chen, J. C. Chen, C. J. Ng, D. F. Chiu, and M. F. Chen, “Melatonin reduces pancreatic prostaglandins production and protects against caerulein-induced pancreatitis in rats,” Journal of Pineal Research, vol. 40, no. 1, pp. 34–39, 2006. View at Publisher · View at Google Scholar · View at Scopus
  60. K. Gülben, H. Özdemir, U. Berberoǧlu et al., “Melatonin modulates the severity of taurocholate-induced acute pancreatitis in the rat,” Digestive Diseases and Sciences, vol. 55, no. 4, pp. 941–946, 2010. View at Publisher · View at Google Scholar
  61. F. C. Muñoz-Casares, F. J. Padillo, J. Briceño et al., “Melatonin reduces apoptosis and necrosis induced by ischemia/reperfusion injury of the pancreas,” Journal of Pineal Research, vol. 40, no. 3, pp. 195–203, 2006. View at Publisher · View at Google Scholar
  62. G. Soybir, C. Topuzlu, O. Odabaş, K. Dolay, A. Bilir, and F. Köksoy, “The effects of melatonin on angiogenesis and wound healing,” Surgery Today, vol. 33, no. 12, pp. 896–901, 2003. View at Publisher · View at Google Scholar · View at Scopus
  63. H. Zhu, K. Itoh, M. Yamamoto, J. L. Zweier, and Y. Li, “Role of Nrf2 signaling in regulation of antioxidants and phase 2 enzymes in cardiac fibroblasts: protection against reactive oxygen and nitrogen species-induced cell injury,” FEBS Letters, vol. 579, no. 14, pp. 3029–3036, 2005. View at Publisher · View at Google Scholar · View at Scopus
  64. R. Jockers, P. Maurice, J. A. Boutin, and P. Delagrange, “Melatonin receptors, heterodimerization, signal transduction and binding sites: what's new?” British Journal of Pharmacology, vol. 154, no. 6, pp. 1182–1195, 2008. View at Publisher · View at Google Scholar · View at Scopus
  65. R. Hardeland, “Melatonin: signaling mechanisms of a pleiotropic agent,” BioFactors, vol. 35, no. 2, pp. 183–192, 2009. View at Publisher · View at Google Scholar · View at Scopus
  66. E. J. X. Costa, C. S. Shida, M. H. Biaggi, A. S. Ito, and M. T. Lamy-Freund, “How melatonin interacts with lipid bilayers: a study by fluorescence and ESR spectroscopies,” FEBS Letters, vol. 416, no. 1, pp. 103–106, 1997. View at Publisher · View at Google Scholar
  67. G. A. Bubenik and S. J. Konturek, “Melatonin and aging: prospects for human treatment,” Journal of Physiology and Pharmacology, vol. 62, no. 1, pp. 13–19, 2011. View at Google Scholar
  68. W. Qi, D. X. Tan, R. J. Reiter et al., “Melatonin reduces lipid peroxidation and tissue edema in cerulein- induced acute pancreatitis in rats,” Digestive Diseases and Sciences, vol. 44, no. 11, pp. 2257–2262, 1999. View at Google Scholar · View at Scopus
  69. A. Baykal, A. B. Iskit, E. Hamaloglu, M. Oguz Guc, G. Hascelik, and I. Sayek, “Melatonin modulates mesenteric blood flow and TNFα concentrations after lipopolysaccharide challenge,” European Journal of Surgery, vol. 166, no. 9, pp. 722–727, 2000. View at Google Scholar · View at Scopus
  70. J. Jaworek, S. J. Konturek, A. Leja-Szpak et al., “Role of endogenous melatonin and its MT2 receptor in the modulation of caerulein-induced pancreatitis in the rat,” Journal of Physiology and Pharmacology, vol. 53, no. 4, pp. 791–804, 2002. View at Google Scholar · View at Scopus
  71. J. Jaworek, K. Zwirska-Korczala, J. Szklarczyk et al., “Pinealectomy aggravates acute pancreatitis in the rat,” Pharmacological Reports, vol. 62, no. 5, pp. 864–873, 2010. View at Google Scholar
  72. A. Szabolcs, R. J. Reiter, T. Letoha et al., “Effect of melatonin on the severity of L-arginine-induced experimental acute pancreatitis in rats,” World Journal of Gastroenterology, vol. 12, no. 2, pp. 251–258, 2006. View at Google Scholar · View at Scopus
  73. M. Eşrefoǧlu, M. Gül, B. Ateş, and M. A. Selimoǧlu, “Ultrastructural clues for the protective effect of melatonin against oxidative damage in cerulein-induced pancreatitis,” Journal of Pineal Research, vol. 40, no. 1, pp. 92–97, 2006. View at Publisher · View at Google Scholar · View at Scopus
  74. J. Jaworek, S. J. Konturek, R. Tomaszewska et al., “The circadian rhythm of melatonin modulates the severity of caerulein-induced pancreatitis in the rat,” Journal of Pineal Research, vol. 37, no. 3, pp. 161–170, 2004. View at Publisher · View at Google Scholar · View at Scopus
  75. C. Çöl, K. Dinler, A. O. Hasdemir, and G. Bugdayci, “The effect of an intraperitoneal injection of melatonin on serum amylase levels in acute pancreatitis,” Journal of the Pancreas, vol. 10, no. 3, pp. 306–309, 2009. View at Google Scholar · View at Scopus
  76. S. Sidhu, P. Pandhi, S. Malhotra, K. Vaiphei, and K. L. Khanduja, “Melatonin treatment is beneficial in pancreatic repair process after experimental acute pancreatitis,” European Journal of Pharmacology, vol. 628, no. 1-3, pp. 282–289, 2010. View at Publisher · View at Google Scholar
  77. E. Alhan, N. I. Kalyoncu, B. V. Kural, and C. Erçin, “Effects of melatonin on acute necrotizing pancreatitis in rats,” Zeitschrift fur Gastroenterologie, vol. 42, no. 9, pp. 967–972, 2004. View at Publisher · View at Google Scholar
  78. O. Belyaev, T. Herzog, J. Munding et al., “Protective role of endogenous melatonin in the early course of human acute pancreatitis,” Journal of Pineal Research, vol. 50, no. 1, pp. 71–77, 2011. View at Publisher · View at Google Scholar · View at Scopus
  79. J. Jaworek, “Ghrelin and melatonin in the regulation of pancreatic exocrine secretion and maintaining of integrity,” Journal of Physiology and Pharmacology, vol. 57, no. 5, pp. 83–96, 2006. View at Google Scholar · View at Scopus
  80. A. Leja-Szpak, J. Jaworek, P. Pierzchalski, and R. J. Reiter, “Melatonin induces pro-apoptotic signaling pathway in human pancreatic carcinoma cells (PANC-1),” Journal of Pineal Research, vol. 49, no. 3, pp. 248–255, 2010. View at Publisher · View at Google Scholar · View at Scopus
  81. A. L. Joly, G. Wettstein, G. Mignot, F. Ghiringhelli, and C. Garrido, “Dual role of heat shock proteins as regulators of apoptosis and innate immunity,” Journal of Innate Immunity, vol. 2, no. 3, pp. 238–247, 2010. View at Publisher · View at Google Scholar · View at Scopus
  82. J. Bonior, J. Jaworek, S. J. Konturek, and W. W. Pawlik, “Increase of heat shock protein gene expression by melatonin in AR42J cells,” Journal of Physiology and Pharmacology, vol. 56, no. 3, pp. 471–481, 2005. View at Google Scholar · View at Scopus
  83. P. Lissoni, “Is there a role for melatonin in supportive care?” Supportive Care in Cancer, vol. 10, no. 2, pp. 110–116, 2002. View at Publisher · View at Google Scholar · View at Scopus
  84. F. Castro, E. Carrizo, D. Prieto de Rincón et al., “Effectiveness of melatonin in tardive dyskinesia,” Investigación clínica, vol. 52, no. 3, pp. 252–260, 2011. View at Google Scholar
  85. D. P. Cardinali, E. S. Pagano, P. A. Scacchi Bernasconi, R. Reynoso, and P. Scacchi, “Disrupted chronobiology of sleep and cytoprotection in obesity: possible therapeutic value of melatonin,” Neuroendocrinology Letters, vol. 32, no. 5, pp. 588–606, 2011. View at Google Scholar