Patterns of Pathomorphological Changes in Acute Necrotizing Pancreatitis

Table 1

Early, late, and protective changes in pancreatic tissue in patients with APN.

Microscopic changes	Number of	Percentage
	patients
Early changes
Vascular endothelial desquamation	224	100%
Intravascular stasis and sludge	215	95.9%
Circular thrombosis	99	44.2%
Mucoid swelling in stromal carcass	40	17.9%
Parenchymal hemorrhages	208	92.9%
Late changes
Parenchymal necrosis	224	100%
Total thromboses	206	92%
Thrombolysis and recanalization	49	21.9%
Decomposition of argyrophilic	211	94.2%
reticular carcass
Fibrinoid swelling	164	73.2%
Calcium accumulation	34	15.2%
Protective changes
Nerves resistant to necrosis	179	79.9%
Lobular ducts resistant to necrosis	175	78.1%
Islets of Langerhans resistant to	166	74.1%
necrosis