Resident Corneal Cells Communicate with Neutrophils Leading to the Production of IP-10 during the Primary Inflammatory Response to HSV-1 Infection
Figure 2
Expression of IP-10 mRNA is upregulated during the first 48 hours of HSV-1 infection of the cornea. Mice () were challenged by intrastromal injection with PFU HSV-1 and corneas were harvested at the indicated times post infection. Control mice were uninfected and corneas from this group represented the level of constitutive mRNA production for each chemokine. Total RNA was isolated from each group and converted to cDNA which was analyzed by real-time PCR. Upregulation in mRNA for each chemokine is reported as the fold increase over production in uninfected control corneas.
