Resident Corneal Cells Communicate with Neutrophils Leading to the Production of IP-10 during the Primary Inflammatory Response to HSV-1 Infection
Figure 3
IP-10 is produced at significant levels in the HSV-1 infected cornea. Mice were infected with 2 × 105 PFU HSV-1 on the scarified cornea. Mice were monitored for corneal opacity (graph (a), open circle, ∘) an asterisk indicates a significant increase between day 1 and 8. At the indicated time points corneas () were excised and lysates produced for virus titration (graph (a), closed box, ■), an asterisk indicates a significant reduction from day 1 to day 8 (-test) and the medians for the data are found to be significantly different by a nonparametric test (Kruskal-Wallis test). Levels of IP-10 protein production within the infected corneal lysates are shown in (b). N.D. = not done.
