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International Journal of Inflammation
Volume 2013, Article ID 309493, 5 pages
http://dx.doi.org/10.1155/2013/309493
Research Article

Effects of Flavonoids from French Marigold (Florets of Tagetes patula L.) on Acute Inflammation Model

1School of Pharmacy, Nihon University, Chiba 274-8555, Japan
2The Yamagata Prefectural Institute of Public Health, Yamagata 990-0031, Japan

Received 10 June 2013; Accepted 7 August 2013

Academic Editor: David A. Hart

Copyright © 2013 Ken Yasukawa and Yoshimasa Kasahara. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

The major components patuletin and patulitrin were isolated from French marigold (florets of Tagetes patula). Patuletin and patulitrin were found to inhibit acute inflammation in mice. Oral administration of patuletin and patulitrin significantly suppressed hind-paw edema induced by carrageenin and histamine, while topical application of patuletin and patulitrin significantly inhibited ear edema induced by 12-O-tetradecanoylphorbol-13-acetate and arachidonic acid. Thus, oral and topical administration of patuletin and patulitrin inhibited acute inflammation in mice. These results suggest the anti-inflammatory efficacy of French marigold.