Research Article

Statin Modulation of Human T-Cell Proliferation, IL-1 and IL-17 Production, and IFN- T Cell Expression: Synergy with Conventional Immunosuppressive Agents

Table 1

Spearman rank analysis of correlations in cytokines produced by cells cultured with PMA/ionomycin ± statins ± dexamethasone. The values represent the strength of the correlation of cytokines, with +1.00 being the maximum, and their changes in expression according to exposure to each statins. All results were statistically significant ( ).

No drugAtorvastatinSimvastatinLovastatinDexAtorvastatin and  dex
IFNγTNFαIL-2IFNγTNFαIL-1bIL-2IFNγIL-5IFNγTNFαIL-5IFNγIL-1βIFNγTNFα

IL-2+0.89+1.00+0.99+0.89−0.94+0.94

IL-6+0.89+0.89+0.89 +0.93+0.94+1.00+0.89+0.94+0.89+0.99+0.94

IFNγ+0.99+0.99−0.89

IL-10+0.89