Anti-Inflammatory Effect of Emblica officinalis in Rodent Models of Acute and Chronic Inflammation: Involvement of Possible Mechanisms

Table 1

Effect of HAEEO on oxidative stress parameters in carrageenan-induced paw edema in rats.

Treatment	GSH (µg g^−1 tissue)	MDA (nmol g^−1 tissue)	SOD (Um g^−1 protein)	Catalase (Um g^−1 protein)
Normal control	32.91 ± 2.13	27.14 ± 2.96	40.54 ± 2.23	57.19 ± 2.48
Carrageenan control (vehicle treated)	13.33 ± 1.39^a	88.45 ± 4.79^a	15.19 ± 1.21^a	14.48 ± 0.75^a
Indomethacin (10 mg kg^−1)	26.66 ± 1.66^b	28.54 ± 6.85^b	31.96 ± 1.08^b	49.30 ± 1.86^b
HAEEO (300 mg kg^−1)	19.16 ± 1.53	63.18 ± 4.51^d	21.18 ± 1.80	27.44 ± 1.66^b
HAEEO (500 mg kg^−1)	22.29 ± 2.80^d	49.14 ± 5.83^b	24.87 ± 0.98^d	36.1 ± 0.83^b
HAEEO (700 mg kg^−1)	26.25 ± 2.18^c	35.10 ± 2.78^b	29 ± 1.66^b	41.82 ± 1.41^b

Values given are mean ± S.E.M. ( = 6). ^aP < 0.001 compared to normal control and ^bP < 0.001, ^cP < 0.01, and ^dP < 0.05 compared to carrageenan control. HAEEO: hydroalcoholic extract of Emblica officinalis; GSH: glutathione; MDA: malondialdehyde; SOD: superoxide dismutase.