Research Article

Differential Role of Rapamycin and Torin/KU63794 in Inflammatory Response of 264.7 RAW Macrophages Stimulated by CA-MRSA

Table 1

The table indicates the reduction from the control of RAW264.7 macrophages inflammatory response in the presence of 0, 2.5, 5, and 10 ng/mL Torin (up) and KU63794 (down).

TNF
(%-pg/mL)
IL-1
(%-pg/mL)
IL-6
(%-pg/mL)
INF
(%-pg/mL)
NO
(%-μM)

Torin (ng/mL)
 0100%
33,561 ± 4,027
100%
555 ± 83
100%
845 ± 127
100%
96 ± 14
100%
25.3 ± 3.8
 2.568%*44%*54%*37%*51%*
 548%*43%*49%*40%*48%*
 1046%*44%*48%*41%*46%*
KU63794 (ng/mL)
 0100%
32,865 ± 3,615
100%
432 ± 52
100%
743 ± 89
100%
95 ± 11
100%
23.2 ± 2.8
 2.569%*47%*55%*48%*42%*
 553%*47%*52%*33%*48%*
 1049%*44%*48%*41%*51%*

The first line indicates the response without Torin or KU63794 (0 ng/mL) which is used as control (100% response) and the subsequent values are expressed as % of such responses.
*Indicates statistical significance ( ) from the control.
TNF: tumor necrosis factor, IL-1: interleukin 1, IL-6: interleukin 6, INF: interferon, and NO: nitric oxide.