Anti-Inflammatory and Antiarthritic Activity of Anthraquinone Derivatives in Rodents
Table 7
Effect of AE and AEC on antioxidant levels in Freund’s complete adjuvant induced arthritic rats.
Group ()
LPO (nM of MDA/g of wet tissue)
GSH (μg of GSH/g of wet tissue)
CAT (µM of H2O2/g of wet tissue/minute)
SOD (units/mg of wet tissue)
NO (μM/g of wet tissue)
I-AC
27.16 ± 0.945
17.16 ± 1.138
4.81 ± 0.219
22.20 ± 0.998
50.3 ± 0.905
II-Std.
15.66 ± 0.881∗∗
22.16 ± 0.833∗∗
5.03 ± 0.197∗∗
49.71 ± 0.786∗∗
25.17 ± 0.525∗∗
III-AE 25
24.33 ± 0.7601
19.83 ± 0.872
5.11 ± 0.192
23.89 ± 1.042
47.53 ± 0.496
IV-AE 50
20.33 ± 0.614∗∗
22.16 ± 0.792∗∗
6.18 ± 0.149∗∗
35.37 ± 0.765∗∗
40.37 ± 0.632∗∗
V-AE 75
18.50 ± 1.176∗∗
23.16 ± 0.872∗∗
6.73 ± 0.135∗∗
41.70 ± 1.034∗∗
35.03 ± 0.509∗∗
VI-AEC 25
23.16 ± 0.833∗
20.66 ± 0.614∗
5.48 ± 0.130∗
26.23 ± 0.656∗
47.14 ± 0.521∗
VII-AEC 50
20.16 ± 0.945∗∗
23.00 ± 0.577∗∗
6.26 ± 0.114∗∗
40.35 ± 0.939∗∗
38.58 ± 0.852∗∗
VIII-AEC 75
17.33 ± 0.918∗∗
24.50 ± 0.763∗∗
7.05 ± 0.102∗∗
43.57 ± 0.635∗∗
33.07 ± 0.948∗∗
Results are presented as mean ± SEM (). The data was analysed using one-way analysis of variance (ANOVA) followed by Dunnett test. ∗, ∗∗ when compared with arthritic control group. AC: arthritic control; Std.: Diclofenac sodium 10 mg/kg p.o.; AE: aloe emodin (25, 50, and 75 mg/kg p.o.); AEC: carboxylic acid derivative of aloe emodin (25, 50, and 75 mg/kg p.o.).
