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International Journal of Inflammation
Volume 2014, Article ID 896864, 5 pages
Research Article

Clinical Feature of Intrahepatic B-Lymphocytes in Chronic Hepatitis B

Liver and Pancreatobiliary Diseases Research Center, Digestive Diseases Research Centre, Tehran University of Medical Sciences, Shariati Hospital, North Kargar Avenue, Tehran 14117 13135, Iran

Received 7 September 2013; Accepted 28 October 2013; Published 21 January 2014

Academic Editor: Jean-Marc Cavaillon

Copyright © 2014 Ashraf Mohamadkhani et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


Humoral immunity constitutes major defense mechanism against viral infections. However, the association of hepatic injury and B-cells population in chronic hepatitis B virus (HBV) carriers has not been studied well. In this study, fifty seven hepatitis B surface antigen (HBsAg) positive and HBeAg negative patients were studied to determine the expression of CD20, a cell surface marker expressed on B-cells, in liver biopsy sections using immunohistochemistry. The patients’ clinical data at the time of liver biopsy were acquired from their medical records. There was a significant association between log HBV DNA and both ALT (, ) and histologic activity index (HAI) total score (, ), respectively. The CD20 was expressed in all 57 liver biopsy samples with a submembranous and membranous staining pattern and its expression was significantly associated with HAI total score (, ) and stage of fibrosis (, ). The susceptible B lymphocytes to hepatitis B virus might be implicated in the development of immune mediated inflammation of HBV-induced hepatic injury. The present data also support that the liver is potentially one of the secondary lymphoid organs.