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International Journal of Inflammation
Volume 2014, Article ID 986525, 6 pages
http://dx.doi.org/10.1155/2014/986525
Research Article

The Serum S100B Level as a Biomarker of Enteroglial Activation in Patients with Ulcerative Colitis

1Department of Neurology, Medical School, Bozok University, 66200 Yozgat, Turkey
2Department of Gastroenterology, Medical School, Bozok University, 66200 Yozgat, Turkey
3Department of Medical Biology, Medical School, Bozok University, 66200 Yozgat, Turkey
4Department of Internal Medicine, Medical School, Bozok University, 66200 Yozgat, Turkey
5Department of Gastroenterology, Medical School, Erciyes University, 38039 Kayseri, Turkey
6Department of Internal Medicine, Medical School, Erciyes University, 38039 Kayseri, Turkey
7Department of Pathology, Medical School, Erciyes University, 38039 Kayseri, Turkey
8Department of Infectious Diseases and Microbiology, Medical School, Bozok University, 66200 Yozgat, Turkey

Received 23 December 2013; Revised 6 February 2014; Accepted 6 March 2014; Published 30 March 2014

Academic Editor: Jonathan Steven Alexander

Copyright © 2014 Asuman Celikbilek et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

Objective. Recent studies have demonstrated that enteric glial cells (EGC) participate in the homeostasis of the gastrointestinal tract. This study investigated whether enteroglial markers, including S100B protein and glial fibrillary acidic protein (GFAP), can serve as noninvasive indicators of EGC activation and disease activity in UC patients. Methods. This clinical prospective study included 35 patients with UC and 40 age- and sex-matched controls. The diagnosis of UC was based on standard clinical, radiological, endoscopic, and histological criteria. Clinical disease activity was evaluated using the Modified Truelove-Witts Severity Index. Serum samples were analyzed for human GFAP and S100B using commercial enzyme-linked immunosorbent assay kits. Results. GFAP was not detected in the serum of either UC patients or controls (). However, we found a significant () decrease in the serum S100B levels in the UC patients. No correlation between the serum S100B level and the disease activity or duration was observed (). The serum S100B levels did not differ between UC patients with active disease (24 patients, 68.6%) or in remission (11 patients, 31.4%) (). Conclusions. Ulcerative colitis patients had significantly lower serum S100B levels, while GFAP was of no diagnostic value in UC patients.