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International Journal of Inflammation
Volume 2015 (2015), Article ID 329792, 8 pages
http://dx.doi.org/10.1155/2015/329792
Research Article

Serum Levels of Proinflammatory Cytokines in Painful Knee Osteoarthritis and Sensitization

1Clinical Research Center, Institute of Physical Medicine and Rehabilitation, University of São Paulo School of Medicine, Rua Jandiatuba, 580 Vila Andrade, 05716-150 São Paulo, SP, Brazil
2University of São Paulo School of Medicine, Avenida Dr. Arnaldo, 455 Cerqueira César, 01246903 São Paulo, SP, Brazil
3São Paulo Adventist University Center, Estrada de Itapecerica, 5859 Jardim IAE, 05858-001 São Paulo, SP, Brazil
4Tropical Hematology Laboratory, Institute of Tropical Medicine of São Paulo and Medical Research Laboratory, LIM 52, University of São Paulo, Avenida Dr. Arnaldo, 455 Cerqueira César, 01246903 São Paulo, SP, Brazil
5Institute of Physical Medicine and Rehabilitation, University of São Paulo School of Medicine, Rua Domingo de Soto 100, Vila Mariana, 04116-030 São Paulo, SP, Brazil
6Department of Physical Medicine and Rehabilitation, Hacettepe University Medical School, Hacettepe University Faculty of Medicine, Sıhhiye, 06100 Ankara, Turkey
7Center for Sensory-Motor Interaction, School of Medicine, Aalborg University, Fredrik Bajers Vej 7, Building D3, 9220 Aalborg E, Denmark

Received 12 November 2014; Revised 23 December 2014; Accepted 23 January 2015

Academic Editor: David A. Hart

Copyright © 2015 Marta Imamura et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

Osteoarthritis (OA) is the most common joint disorder in the world. Among the mechanisms involved in osteoarthritis, biomarkers (cytokines profile) may be related to pain and pain intensity, functional capacity, and pressure pain thresholds (PPT). Thus, the study of these relationships may offer useful information about pathophysiology and associated mechanisms involved in osteoarthritis. Therefore, the objective of this study was to investigate the seric concentration of pro (IL-6, IL-8, and TNF-α) and anti-inflammatory (IL-10) cytokines in patients with painful knee osteoarthritis and to correlate the levels of these biomarkers with the patients’ functional capacity and pressure pain threshold (PPT) values.