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International Journal of Inflammation
Volume 2015, Article ID 970890, 10 pages
Review Article

Angiogenesis in Inflammatory Bowel Disease

Department of Gastroenterology, Şişli Hamidiye Etfal Training and Research Hospital, Şişli, 34360 Istanbul, Turkey

Received 29 September 2015; Revised 7 December 2015; Accepted 8 December 2015

Academic Editor: G. Rogler

Copyright © 2015 Canan Alkim et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


Angiogenesis is an important component of pathogenesis of inflammatory bowel disease (IBD). Chronic inflammation and angiogenesis are two closely related processes. Chronic intestinal inflammation is dependent on angiogenesis and this angiogenesis is modulated by immune system in IBD. Angiogenesis is a very complex process which includes multiple cell types, growth factors, cytokines, adhesion molecules, and signal transduction. Lymphangiogenesis is a new research area in the pathogenesis of IBD. While angiogenesis supports inflammation via leukocyte migration, carrying oxygen and nutrients, on the other hand, it has a major role in wound healing. Angiogenic molecules look like perfect targets for the treatment of IBD, but they have risk for serious side effects because of their nature.