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International Journal of Inflammation
Volume 2016, Article ID 1532832, 11 pages
http://dx.doi.org/10.1155/2016/1532832
Review Article

The Role of TLR2, TLR4, and TLR9 in the Pathogenesis of Atherosclerosis

Department of Anatomy, Faculty of Medicine and Surgery, University of Malta, Msida, Malta

Received 17 July 2016; Revised 5 September 2016; Accepted 15 September 2016

Academic Editor: Jean-Marc Cavaillon

Copyright © 2016 Mohsin H. K. Roshan et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Citations to this Article [19 citations]

The following is the list of published articles that have cited the current article.

  • Saskia C.A. de Jager, John A.L. Meeuwsen, Freeke M. van Pijpen, Gerbrand A. Zoet, Arjan D. Barendrecht, Arie Franx, Gerard Pasterkamp, Bas B. van Rijn, Marie-José Goumans, and Hester M. den Ruijter, “Preeclampsia and coronary plaque erosion: manifestations of endothelial dysfunction resulting in cardiovascular events in women,” European Journal of Pharmacology, 2017. View at Publisher · View at Google Scholar
  • Priscilla Souza, Aline Marcadenti, and Vera Portal, “Effects of Olive Oil Phenolic Compounds on Inflammation in the Prevention and Treatment of Coronary Artery Disease,” Nutrients, vol. 9, no. 10, pp. 1087, 2017. View at Publisher · View at Google Scholar
  • Yuanjun Zhang, Jinxing Quan, Xiaowei Liu, Yaya Lv, Suhong Wei, Guanghao Xia, Yaqiong Zhang, Juxiang Liu, Weihua Li, and Jing Liu, “Palmitate induces VSMC apoptosis via toll like receptor (TLR)4/ROS/p53 pathway,” Atherosclerosis, vol. 263, pp. 74–81, 2017. View at Publisher · View at Google Scholar
  • Jenny Jongstra-Bilen, Cindy X. Zhang, Timothy Wisnicki, Mengyi K. Li, Samantha White-Alfred, Ragave Ilaalagan, Dario M. Ferri, Ashley Deonarain, Mark H. Wan, Sharon J. Hyduk, Carolyn L. Cummins, and Myron I. Cybulsky, “Oxidized Low-Density Lipoprotein Loading of Macrophages Downregulates TLR-Induced Proinflammatory Responses in a Gene-Specific and Temporal Manner through Transcriptional Control,” The Journal of Immunology, vol. 199, no. 6, pp. 2149–2157, 2017. View at Publisher · View at Google Scholar
  • Laleh Sharifi, Abbas Mirshafiey, Asghar Aghamohammadi, Mona Moshiri, Anis Barati, Seyed Javad Sayedi, Golamreza Azizi, Monireh Mohsenzadegan, Nima Rezaei, Farzaneh Tofighi Zavareh, and Saied Bokaie, “Immunomodulation of TLR2 and TLR4 by G2013 (α-L-Guluronic acid) in CVID patients,” International Journal of Pediatrics, vol. 5, no. 7, pp. 5327–5337, 2017. View at Publisher · View at Google Scholar
  • Zigong Shao, Baoping Jiao, Dehui Yi, Tingting Liu, Qi Pan, Ying Cheng, and Hao Liu, “Prevention of TLR9 pathway in warm ischemia in porcine donor liver after cardiac death,” Cellular Physiology and Biochemistry, vol. 41, no. 4, pp. 1547–1554, 2017. View at Publisher · View at Google Scholar
  • Haijian Sun, Xuexue Zhu, Weiwei Cai, and Liying Qiu, “Hypaphorine Attenuates Lipopolysaccharide-Induced Endothelial Inflammation via Regulation of TLR4 and PPAR-γ Dependent on PI3K/Akt/mTOR Signal Pathway,” International Journal of Molecular Sciences, vol. 18, no. 4, pp. 844, 2017. View at Publisher · View at Google Scholar
  • Felipe Vendrame, Leticia Olops, Sara Terezinha Olalla Saad, Fernando Ferreira Costa, and Kleber Yotsumoto Fertrin, “Differences in heme and hemopexin content in lipoproteins from patients with sickle cell disease,” Journal of Clinical Lipidology, 2018. View at Publisher · View at Google Scholar
  • Rebekka Bent, Lorna Moll, Stephan Grabbe, and Matthias Bros, “Interleukin-1 Beta—A Friend or Foe in Malignancies?,” International Journal of Molecular Sciences, vol. 19, no. 8, pp. 2155, 2018. View at Publisher · View at Google Scholar
  • Xiao-Jie Cao, Ming-Jie Zhang, Li-Li Zhang, Ke Yu, Yang Xiang, Xin Ding, Jin Fan, Jing-Cheng Li, and Qing-Song Wang, “TLR4 mediates high-fat diet induced physiological changes in mice via attenuating PPARγ/ABCG1 signaling pathway,” Biochemical and Biophysical Research Communications, 2018. View at Publisher · View at Google Scholar
  • Silvia Ferronato, Alberto Scuro, Macarena Gomez-Lira, Sara Mazzucco, Silvia Olivato, Alberto Turco, Orlandi Elisa, Giovanni Malerba, and Maria Grazia Romanelli, “Correlations between gene expression highlight a different activation of ACE/TLR4/PTGS2 signaling in symptomatic and asymptomatic plaques in atherosclerotic patients,” Molecular Biology Reports, 2018. View at Publisher · View at Google Scholar
  • G. Franck, P. Libby, and G. Caligiuri, “Mécanismes d’érosion superficielle des plaques d’athérosclérose,” Archives des Maladies du Coeur et des Vaisseaux - Pratique, 2018. View at Publisher · View at Google Scholar
  • Xian-Jin Du, Jing-Min Lu, and Yin Sha, “MiR-181a inhibits vascular inflammation induced by ox-LDL via targeting TLR4 in human macrophages,” Journal of Cellular Physiology, 2018. View at Publisher · View at Google Scholar
  • Andres Laguna-Fernandez, Antonio Checa, Miguel Carracedo, Gonzalo Artiach, Marcelo H Petri, Roland Baumgartner, Maria J Forteza, Xintong Jiang, Teodora Andonova, Mary E Walker, Jesmond Dalli, Hildur Arnardottir, Anton Gisterå, Silke Thul, Craig E Wheelock, Gabrielle Paulsson-Berne, Daniel FJ Ketelhuth, Göran K Hansson, and Magnus Bäck, “ERV1/ChemR23 Signaling Protects from Atherosclerosis by Modifying oxLDL Uptake and Phagocytosis in Macrophages,” Circulation, pp. 1, 2018. View at Publisher · View at Google Scholar
  • He Huang, Li Cong, Jianguo Cao, Yong Zhang, and Xiaohua Fu, “DFMG reverses proliferation and migration of vascular smooth muscle cells induced by co-culture with injured vascular endothelial cells via suppression of the TLR4-mediated signaling pathway,” Molecular Medicine Reports, vol. 17, no. 4, pp. 5692–5699, 2018. View at Publisher · View at Google Scholar
  • Javad Sargolzaei, Elham Chamani, Tooba Kazemi, Soudabeh Fallah, and Hosna Soori, “The role of adiponectin and adipolin as anti-inflammatory adipokines in the formation of macrophage foam cells and their association with cardiovascular diseases,” Clinical Biochemistry, 2018. View at Publisher · View at Google Scholar
  • Hui Zhi, Jiang-Ping Wu, Lin-Ming Lu, Yan Li, Xiao-Yun Chen, Jun Tao, and Bi-Xian Mai, “Decabromodiphenyl ether (BDE-209) enhances foam cell formation in human macrophages via augmenting Toll-like receptor 4-dependent lipid uptake,” Food and Chemical Toxicology, vol. 121, pp. 367–373, 2018. View at Publisher · View at Google Scholar
  • Xiao Liang, Chunhong Xiu, Minghao Liu, Chaolan Lin, Hanchen Chen, Rui Bao, Shusen Yang, and Jiangbo Yu, “Platelet-neutrophil interaction aggravates vascular inflammation and promotes the progression of atherosclerosis by activating the TLR4/NF-κB pathway,” Journal of Cellular Biochemistry, 2018. View at Publisher · View at Google Scholar
  • Shanshan Zhang, Jun Zou, Peiyang Li, Xiumei Zheng, and Dan Feng, “Curcumin Protects against Atherosclerosis in Apolipoprotein E-Knockout Mice by Inhibiting Toll-like Receptor 4 Expression,” Journal of Agricultural and Food Chemistry, 2018. View at Publisher · View at Google Scholar