International Journal of Inflammation / 2017 / Article / Tab 4

Research Article

Neutrophil Extracellular Trap Production in Patients with Colorectal Cancer In Vitro

Table 4

Stratified results of quantification of NET formation assay.

NET production (AFU), median (IQR)

StimulantHealthy control
()
Colorectal cancer
()
value

Unstimulated9735 (6429–11840)11347 (4927–8341)0.0209
PMA42173 (35243–52315)39238 (29497–47988)0.2353
IL-88644 (6098–12304)11915 (9031–15358)0.0032
LPS10576 (7366–12946)12473 (9381–16542)0.0428
fMLP9566 (8345–11973)12194 (8602–15991)0.0868

StimulantRectal cancer
()
Colonic cancer
()
value

Unstimulated10190 (8057–14580)12140 (9980–1499)0.2711
PMA39490 (29050–49190)38100 (29370–48840)0.8078
IL-811080 (8245–15610)11960 (9998–15350)0.4655
LPS11600 (8515–15580)12730 (11210–18640)0.2813
fMLP10520 (8384–14910)12440 (9203–16850)0.4241

StimulantEarly stage (Dukes’ A/B)
()
Late stage (Dukes’ C/D)
()
value

Unstimulated11340 (8862–14880)11350 (7476–15150)0.7353
PMA39490 (29640–47200)38100 (27730–48530)0.8314
IL-811990 (9574–15750)10320 (7790–14820)0.3105
LPS12600 (9783–16280)11540 (9106–17270)0.6795
fMLP12200 (8500–16050)11780 (8624–14840)0.6432

StimulantNeoadjuvant therapy
()
Straight to surgery
()
value

Unstimulated9039 (7507–13230)11780 (9031–15460)0.1577
PMA34830 (27140–41590)40330 (29560–49070)0.2002
IL-810320 (8306–15190)12010 (9349–15980)0.2295
LPS13900 (8323–14930)12380 (10070–17120)0.4516
fMLP11400 (8339–15870)12330 (8704–17200)0.4205

StimulantClavien-Dindo < 3
()
Clavien-Dindo ≥ 3
()
value

Unstimulated11090 (8240–14670)14780 (12630–18330)0.0639
PMA38100 (29620–47760)40330 (27690–60140)0.6522
IL-811820 (8517–14300)15840 (11300–19070)0.0796
LPS12290 (8858–15750)15180 (11620–19710)0.2359
fMLP11760 (8339–14510)18340 (12330–22400)0.0242

StimulantLOS ≤ 5 days
()
LOS > 5 days
()
value

Unstimulated11090 (7507–14200)12140 (8879–15260)0.3220
PMA36430 (27510–43650)39740 (29500–50280)0.2760
IL-811840 (7935–14200)12250 (9261–6443)0.4576
LPS9408 (6915–15170)13180 (11250–17270)0.1812
fMLP9008 (7599–13290)12530 (10690–17940)0.0476

StimulantSurvived
()
Died
()
value

Unstimulated11180 (8301–14640)14760 (10340–18880)0.2707
PMA38670 (29640–45400)50810 (25310–74680)0.3033
IL-811830 (9004–14970)15370 (10960–20510)0.1644
LPS12290 (8982–16280)13900 (12360–20780)0.2405
fMLP11680 (8354–14530)16110 (12310–234200.0533

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