Table of Contents Author Guidelines Submit a Manuscript
International Journal of Inflammation
Volume 2018 (2018), Article ID 2157434, 6 pages
https://doi.org/10.1155/2018/2157434
Research Article

Impaired Inflammatory Response to LPS in Type 2 Diabetes Mellitus

1Group of Cell Technologies, Institute of Molecular Biology, National Academy of Sciences, Yerevan, Armenia
2Laboratory of Molecular and Cellular Immunology, Institute of Molecular Biology, National Academy of Sciences, Yerevan, Armenia
3Russian-Armenian (Slavonic) University, Yerevan, Armenia

Correspondence should be addressed to Gayane Manukyan; moc.liamg@naykunam.ayag

Received 12 October 2017; Accepted 14 December 2017; Published 14 January 2018

Academic Editor: B. L. Slomiany

Copyright © 2018 Lusine Khondkaryan et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Linked References

  1. L. Guariguata, D. Whiting, I. Hambleton, J. Beagley, U. Linnenkamp, and J. Shaw, “Global estimates of diabetes prevalence for 2013 and projections for 2035,” Diabetes Research and Clinical Practice, vol. 103, no. 2, pp. 137–149, 2014. View at Publisher · View at Google Scholar
  2. F. M. Ashcroft and P. Rorsman, “Diabetes mellitus and the β cell: the last ten years,” Cell, vol. 148, no. 6, pp. 1160–1171, 2012. View at Publisher · View at Google Scholar · View at Scopus
  3. K. E. Wellen and G. S. Hotamisligil, “Inflammation, stress, and diabetes,” The Journal of Clinical Investigation, vol. 115, no. 5, pp. 1111–1119, 2005. View at Publisher · View at Google Scholar · View at Scopus
  4. M. Y. Donath and S. E. Shoelson, “Type 2 diabetes as an inflammatory disease,” Nature Reviews Immunology, vol. 11, no. 2, pp. 98–107, 2011. View at Publisher · View at Google Scholar · View at Scopus
  5. L. M. A. J. Muller, K. J. Gorter, E. Hak et al., “Increased risk of common infections in patients with type 1 and type 2 diabetes mellitus,” Clinical Infectious Diseases, vol. 41, no. 3, pp. 281–288, 2005. View at Publisher · View at Google Scholar · View at Scopus
  6. A. Y. Peleg, T. Weerarathna, J. S. McCarthy, and T. M. E. Davis, “Common infections in diabetes: pathogenesis, management and relationship to glycaemic control,” Diabetes/Metabolism Research and Reviews, vol. 23, no. 1, pp. 3–13, 2007. View at Publisher · View at Google Scholar · View at Scopus
  7. A. Lecube, G. Pachón, J. Petriz, C. Hernández, and R. Simó, “Phagocytic activity is impaired in type 2 diabetes mellitus and increases after metabolic improvement,” PLoS ONE, vol. 6, no. 8, Article ID e23366, 2011. View at Publisher · View at Google Scholar · View at Scopus
  8. S. Chanchamroen, C. Kewcharoenwong, W. Susaengrat, M. Ato, and G. Lertmemongkolchai, “Human polymorphonuclear neutrophil responses to Burkholderia pseudomallei in healthy and diabetic subjects,” Infection and Immunity, vol. 77, no. 1, pp. 456–463, 2009. View at Publisher · View at Google Scholar · View at Scopus
  9. D. Riyapa, S. Buddhisa, S. Korbsrisate et al., “Neutrophil extracellular traps exhibit antibacterial activity against Burkholderia pseudomallei and are influenced by bacterial and host factors,” Infection and Immunity, vol. 80, no. 11, pp. 3921–3929, 2012. View at Publisher · View at Google Scholar · View at Scopus
  10. B. I. Restrepo, M. Twahirwa, M. H. Rahbar, and L. S. Schlesinger, “Phagocytosis via complement or Fc-gamma receptors is compromised in monocytes from type 2 diabetes patients with chronic hyperglycemia,” PLoS ONE, vol. 9, no. 3, Article ID e92977, 2014. View at Publisher · View at Google Scholar · View at Scopus
  11. M. Delamaire, D. Maugendre, M. Moreno, M.-C. Le Goff, H. Allannic, and B. Genetet, “Impaired leucocyte functions in diabetic patients,” Diabetic Medicine, vol. 14, no. 1, pp. 29–34, 1997. View at Publisher · View at Google Scholar · View at Scopus
  12. P. Pia̧tkiewicz, T. Miłek, M. Bernat-Karpińska, M. Ohams, A. Czech, and P. Ciostek, “The dysfunction of nk cells in patients with type 2 diabetes and colon cancer,” Archivum Immunologiae et Therapia Experimentalis, vol. 61, no. 3, pp. 245–253, 2013. View at Publisher · View at Google Scholar · View at Scopus
  13. K. L. Summers, A. M. Marleau, J. L. Mahon, R. McManus, I. Hramiak, and B. Singh, “Reduced IFN-α secretion by blood dendritic cells in human diabetes,” Clinical Immunology, vol. 121, no. 1, pp. 81–89, 2006. View at Publisher · View at Google Scholar · View at Scopus
  14. P. D. Cani, R. Bibiloni, C. Knauf et al., “Changes in gut microbiota control metabolic endotoxemia-induced inflammation in high-fat diet-induced obesity and diabetes in mice,” Diabetes, vol. 57, no. 6, pp. 1470–1481, 2008. View at Publisher · View at Google Scholar · View at Scopus
  15. P. D. Cani, J. Amar, M. A. Iglesias et al., “Metabolic endotoxemia initiates obesity and insulin resistance,” Diabetes, vol. 56, no. 7, pp. 1761–1772, 2007. View at Google Scholar
  16. C. Auffray, M. H. Sieweke, and F. Geissmann, “Blood monocytes: development, heterogeneity, and relationship with dendritic cells,” Annual Review of Immunology, vol. 27, pp. 669–692, 2009. View at Publisher · View at Google Scholar · View at Scopus
  17. S. Akira, S. Uematsu, and O. Takeuchi, “Pathogen recognition and innate immunity,” Cell, vol. 124, no. 4, pp. 783–801, 2006. View at Publisher · View at Google Scholar · View at Scopus
  18. E. Hatanaka, P. T. Monteagudo, M. S. M. Marrocos, and A. Campa, “Neutrophils and monocytes as potentially important sources of proinflammatory cytokines in diabetes,” Clinical & Experimental Immunology, vol. 146, no. 3, pp. 443–447, 2006. View at Publisher · View at Google Scholar · View at Scopus
  19. R. L. Baldeón, K. Weigelt, H. De Wit et al., “Type 2 diabetes monocyte microrna and mrna expression: dyslipidemia associates with increased differentiation-related genes but not inflammatory activation,” PLoS ONE, vol. 10, no. 6, Article ID e0129421, 2015. View at Publisher · View at Google Scholar · View at Scopus
  20. M. Gacka, T. Dobosz, S. Szymaniec, D. Bednarska-Chabowska, R. Adamiec, and A. Sadakierska-Chudy, “Proinflammatory and atherogenic activity of monocytes in Type 2 diabetes,” Journal of Diabetes and its Complications, vol. 24, no. 1, pp. 1–8, 2010. View at Publisher · View at Google Scholar · View at Scopus
  21. A. Giulietti, E. van Etten, L. Overbergh, K. Stoffels, R. Bouillon, and C. Mathieu, “Monocytes from type 2 diabetic patients have a pro-inflammatory profile. 1,25-Dihydroxyvitamin D3 works as anti-inflammatory,” Diabetes Research and Clinical Practice, vol. 77, no. 1, pp. 47–57, 2007. View at Publisher · View at Google Scholar · View at Scopus
  22. S. J. Creely, P. G. McTernan, C. M. Kusminski et al., “Lipopolysaccharide activates an innate immune system response in human adipose tissue in obesity and type 2 diabetes,” American Journal of Physiology—Endocrinology and Metabolism, vol. 292, no. 3, pp. E740–E747, 2007. View at Publisher · View at Google Scholar · View at Scopus
  23. B. Jayashree, Y. S. Bibin, D. Prabhu et al., “Increased circulatory levels of lipopolysaccharide (LPS) and zonulin signify novel biomarkers of proinflammation in patients with type 2 diabetes,” Molecular and Cellular Biochemistry, vol. 388, no. 1-2, pp. 203–210, 2014. View at Publisher · View at Google Scholar · View at Scopus
  24. H. Ghanim, P. Mohanty, R. Deopurkar et al., “Acute modulation of toll-like receptors by insulin,” Diabetes Care, vol. 31, no. 9, pp. 1827–1831, 2008. View at Publisher · View at Google Scholar · View at Scopus
  25. M. R. Dasu, S. Devaraj, L. Zhao, D. H. Hwang, and I. Jialal, “High glucose induces toll-like receptor expression in human monocytes: mechanism of activation,” Diabetes, vol. 57, no. 11, pp. 3090–3098, 2008. View at Publisher · View at Google Scholar · View at Scopus
  26. K. S. Tan, K. O. Lee, K. C. Low et al., “Glutathione deficiency in type 2 diabetes impairs cytokine responses and control of intracellular bacteria,” The Journal of Clinical Investigation, vol. 122, no. 6, pp. 2289–2300, 2012. View at Publisher · View at Google Scholar · View at Scopus
  27. M. J. Sampson, I. R. Davies, J. C. Brown, K. Ivory, and D. A. Hughes, “Monocyte and neutrophil adhesion molecule expression during acute hyperglycemia and after antioxidant treatment in type 2 diabetes and control patients,” Arteriosclerosis, Thrombosis, and Vascular Biology, vol. 22, no. 7, pp. 1187–1193, 2002. View at Publisher · View at Google Scholar · View at Scopus
  28. A. J. van Oostrom, J. P. van Wijk, T. P. Sijmonsma, T. J. Rabelink, and M. Castro Cabezas, “Increased expression of activation markers on monocytes and neutrophils in type 2 diabetes,” The Netherlands Journal of Medicine, vol. 62, no. 9, pp. 320–325, 2004. View at Google Scholar · View at Scopus
  29. M. A. de Vries, A. Alipour, B. Klop et al., “Glucose-dependent leukocyte activation in patients with type 2 diabetes mellitus, familial combined hyperlipidemia and healthy controls,” Metabolism, vol. 64, no. 2, pp. 213–217, 2015. View at Publisher · View at Google Scholar · View at Scopus
  30. S. Gupta, A. Maratha, J. Siednienko et al., “Analysis of inflammatory cytokine and TLR expression levels in Type 2 Diabetes with complications,” Scientific Reports, vol. 7, article 7633, 2017. View at Publisher · View at Google Scholar
  31. R. Medzhitov and T. Horng, “Transcriptional control of the inflammatory response,” Nature Reviews Immunology, vol. 9, no. 10, pp. 692–703, 2009. View at Publisher · View at Google Scholar · View at Scopus
  32. C. Nathan and A. Ding, “Nonresolving inflammation,” Cell, vol. 140, no. 6, pp. 871–882, 2010. View at Publisher · View at Google Scholar · View at Scopus
  33. H. Fan and J. A. Cook, “Molecular mechanism of endotoxin tolerance,” Journal of Endotoxin Research, vol. 10, no. 2, pp. 71–84, 2004. View at Publisher · View at Google Scholar · View at Scopus
  34. E. López-Collazo and C. del Fresno, “Pathophysiology of endotoxin tolerance: mechanisms and clinical consequences,” Critical Care, vol. 17, no. 6, article 242, 2013. View at Publisher · View at Google Scholar · View at Scopus
  35. S. E. Geerlings and A. I. M. Hoepelman, “Immune dysfunction in patients with diabetes mellitus (DM),” FEMS Immunology & Medical Microbiology, vol. 26, no. 3-4, pp. 259–265, 1999. View at Publisher · View at Google Scholar · View at Scopus
  36. J. C. Pickup, G. D. Chusney, S. M. Thomas, and D. Burt, “Plasma interleukin-6, tumour necrosis factor α and blood cytokine production in type 2 diabetes,” Life Sciences, vol. 67, no. 3, pp. 291–300, 2000. View at Publisher · View at Google Scholar · View at Scopus
  37. M. C. Foss-Freitas, N. T. Foss, E. A. Donadi, and M. C. Foss, “In vitro TNF-a and IL-6 production by adherent peripheral blood mononuclear cells obtained from type 1 and type 2 diabetic patients evaluated according to the metabolic control,” Annals of the New York Academy of Sciences, vol. 1079, pp. 177–180, 2006. View at Publisher · View at Google Scholar · View at Scopus
  38. M. R. Chacón, J. Vendrell, M. Miranda et al., “Different TNFα expression elicited by glucose in monocytes from type 2 diabetes mellitus patients,” Atherosclerosis, vol. 194, no. 2, pp. e18–e25, 2007. View at Publisher · View at Google Scholar · View at Scopus
  39. A. S. Andreasen, T. Pedersen-Skovsgaard, R. M. G. Berg et al., “Type 2 diabetes mellitus is associated with impaired cytokine response and adhesion molecule expression in human endotoxemia,” Intensive Care Medicine, vol. 36, no. 9, pp. 1548–1555, 2010. View at Publisher · View at Google Scholar · View at Scopus
  40. J. C. Barry, S. Shakibakho, C. Durrer et al., “Hyporesponsiveness to the anti-inflammatory action of interleukin-10 in type 2 diabetes,” Scientific Reports, vol. 6, Article ID 21244, 2016. View at Publisher · View at Google Scholar · View at Scopus
  41. S. E. Geerlings, E. C. Brouwer, K. C. P. M. Van Kessel, W. Gaastra, R. P. Stolk, and A. I. M. Hoepelman, “Cytokine secretion is impaired in women with diabetes mellitus,” European Journal of Clinical Investigation, vol. 30, no. 11, pp. 995–1001, 2000. View at Publisher · View at Google Scholar · View at Scopus
  42. E. F. Devêvre, M. Renovato-Martins, K. Clément, C. Sautès-Fridman, I. Cremer, and C. Poitou, “Profiling of the three circulating monocyte subpopulations in human obesity,” The Journal of Immunology, vol. 194, no. 8, pp. 3917–3923, 2015. View at Publisher · View at Google Scholar · View at Scopus
  43. L. K. Weaver, P. A. Pioli, K. Wardwell, S. N. Vogel, and P. M. Guyre, “Up-regulation of human monocyte CD163 upon activation of cell-surface Toll-like receptors,” Journal of Leukocyte Biology, vol. 81, no. 3, pp. 663–671, 2007. View at Publisher · View at Google Scholar · View at Scopus
  44. T. H. Sulahian, P. Högger, A. E. Wahner et al., “Human monocytes express CD163, which is upregulated by IL-10 and identical to p155,” Cytokine, vol. 12, no. 9, pp. 1312–1321, 2000. View at Publisher · View at Google Scholar · View at Scopus
  45. O. M. Pena, J. Pistolic, D. Raj, C. D. Fjell, and R. E. W. Hancock, “Endotoxin tolerance represents a distinctive state of alternative polarization (M2) in human mononuclear cells,” The Journal of Immunology, vol. 186, no. 12, pp. 7243–7254, 2011. View at Publisher · View at Google Scholar · View at Scopus
  46. A. B. Alves-Januzzi, M. K. Brunialti, and R. Salomao, “CD163 and CD206 expression does not correlate with tolerance and cytokine production in LPS-tolerant human monocytes,” Cytometry Part B: Clinical Cytometry, vol. 92, no. 3, pp. 192–199, 2017. View at Publisher · View at Google Scholar