Combined Oral Contraceptive Effects on Low-Grade Chronic Inflammatory Mediators in Women with Polycystic Ovary Syndrome: A Systematic Review and Meta-Analysis

Table 2

Risk of bias assessment of the included .

Study, Year	Selection				Comparability of cohorts (matched for)	Outcome			Total score
	Representativeness of exposed cohort	Selection of nonexposed cohort	Ascertainment of exposure	Outcome not present at baseline		Assessment of outcome	Sufficient follow-up duration	Adequate follow-up
Morin-Papunen et al, 2003	∗	∗	∗	–	BMI, age^∗∗	∗	∗	∗	8
Ibanez and de Zegher, 2004	∗	∗	∗	–	BMI^∗	∗	∗	∗	7
Ibanez et al, 2005	∗	∗	∗	–	BMI, age^∗∗	∗	–	∗	7
Cagnacci et al, 2006	∗	∗	∗	–	BMI, age^∗∗	∗	∗	∗	8
Banaszewska et al, 2007	∗	∗	∗	–	Age^∗	∗	–	∗	6
Gul et al, 2008	∗	∗	∗	–	BMI, age^∗∗	∗	–	∗	7
Hoeger et al, 2008	∗	∗	∗	–	BMI, age^∗∗	∗	∗	∗	8
Bilgir et al, 2009	∗	∗	∗	–	BMI, age^∗∗	∗	–	∗	7
Kebapcilar et al, 2010	∗	∗	∗	–	BMI, age^∗∗	∗	–	∗	7
Chen et al, 2010	∗	∗	∗	–	Weight, BMI, age^∗∗∗	∗	–	∗	8
Mancini et al, 2010	∗	∗	∗	–	BMI^∗	∗	∗	∗	7
Teede et al, 2010	∗	∗	∗	–	BMI, age^∗∗	∗	∗	∗	8
Tfayli et al, 2011	∗	∗	∗	–	BMI, age, fat mass^∗∗∗	∗	∗	∗	9
Essah et al, 2011	∗	∗	∗	–	BMI^∗	∗	–	∗	6
Kilic et al, 2011	∗	∗	∗	–	BMI^∗	∗	∗	∗	7
Ibanez et al, 2011	∗	∗	∗	–	BMI, age^∗∗	∗	∗	∗	8
Gode et al, 2011	∗	∗	∗	–	BMI, WC, age^∗∗∗	∗	∗	∗	9
Vieira et al, 2012	∗	∗	∗	–	BMI, age^∗∗	∗	∗	∗	8
Diaz et al, 2012	∗	∗	∗	–	BMI, age^∗∗	∗	∗	∗	8
Harmanci et al, 2013	∗	∗	∗	–	BMI, WHR, age^∗∗∗	∗	∗	∗	9
Ibanez et al, 2013	∗	∗	∗	–	BMI, age^∗∗	∗	∗	∗	8
Christakou et al, 2014	∗	∗	∗	–	BMI, age^∗∗	∗	∗	∗	8
Glintborg et al, 2014	∗	∗	∗	–	BMI, fat mass^∗∗	∗	∗	∗	8
Kahraman et al, 2014	∗	∗	∗	–	BMI, WHR, age^∗∗∗	∗	∗	∗	9
Dardzinska et al, 2014	∗	∗	∗	–	BMI, age^∗∗	∗	∗	∗	7
Yildzhan et al, 2015	∗	∗	∗	–	BMI, WHR, age^∗∗∗	∗	∗	∗	9
Orio et al, 2016	∗	∗	∗	–	BP, BMI, age^∗∗∗	∗	∗	∗	9

a: Newcastle-Ottawa scale, BMI: body mass index, WC: waist circumference, WHR: waist-hip ratio, and BP: blood pressure.