Therapeutic Effects of the Combination of Alpha-Lipoic Acid (ALA) and Coenzyme Q10 (CoQ10) on Cisplatin-Induced Nephrotoxicity

Figure 4

(a) Control: kidney showing average renal capsule (black arrow), average glomeruli (blue arrows), average tubules (red arrow), and average interstitium (H&E ×200). (b) Cisplatin: kidney showing partially detached renal capsule (black arrow), scattered atrophic glomeruli (blue arrows), dilated tubules (yellow arrows), and markedly dilated congested interstitial blood vessels (green arrow) (H&E ×200). (c) Cisplatin + CoQ10: kidney showing average renal capsule (black arrow), scattered atrophic glomeruli (blue arrows), dilated tubules (yellow arrows), and dilated congested blood vessel (red arrow) (H&E ×200). (d) Cisplatin + ALA: kidney showing average renal capsule (black arrow), scattered small-sized glomeruli (blue arrows), and dilated tubules (yellow arrow) (H&E ×200). (e) Cisplatin + CoQ10 + ALA: kidney showing average renal capsule (black arrow), average glomeruli (blue arrows), and mildly congested interstitial blood vessels (yellow arrow) (H&E + 200). (f) Cisplatin + CoQ10 + ALA: high power view showing average glomeruli (G) with average Bowman’s spaces (BS), proximal tubules (P) with edematous epithelial lining (black arrows) and preserved brush borders, and intratubular hyaline casts (blue arrows) (H&E ×400).

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