Therapeutic Effects of the Combination of Alpha-Lipoic Acid (ALA) and Coenzyme Q10 (CoQ10) on Cisplatin-Induced Nephrotoxicity

Table 2

Oxidative stress in the studied groups.

	Group I (N = 8)	Group II (N = 7)	Group III (N = 8)	Group IV (N = 8)	Group V (N = 8)	value in group II (cisplatin) versus other groups	value in group V (combination) versus; groups III, IV (monotherapy)
TNF-α(pg/ml); Mean ± SD	29.45 ± 457	53.92 ± 0.477	47.22 ± 0.376	47.86 ± 0.162	46.02 ± 0.432	0.018	NS
MDA content (nmol/g wet tissue); Mean ± SD	407.21 ± 13.1	702.43 ± 33.21	551.5 ± 9.15	587.75 ± 13.4	433.25 ± 9.62	0.026	0.014
GSH content (mmol/g wet tissue); Mean ± SD	0.366 ± 0.0024	0.1726 ± 0.0059	0.2179 ± 0.0081	0.2011 ± 0.0072	0.2377 ± 0.0049	0.0167	NS
SOD (U/g wet tissue); Mean ± SD	7.57 ± 0.1077	4.16 ± 0.211	6.41 ± 0.1016	6.68 ± 0.055	6.18 ± 0.0529	0.009	NS
CAT (U/g wet tissue); Mean ± SD	0.595 ± 0.0041	0.4653 ± 0.0199	0.5244 ± 0.0063	0.5343 ± 0.0057	0.5728 ± 0.0079	0.011	NS

TNF: tumor necrosis factor. SOD: superoxide dismutase. MDA: malondialdehyde. GSH: glutathione content of renal tissue. CAT: catalase enzyme. Significant. NS: nonsignificant.