Research Article
Influence of Pathogen Type on Neonatal Sepsis Biomarkers
| Parameter | Control | Gram-positive bacteremia | Gram-negative bacteremia | P value |
| MFI nCD24, Me (Q1; Q3) | 9.9 (7.48; 14.1) | 7.16 (4.44; 15.12) | 8.02 (7.48; 20.9) | >0.05 | MFI nCD64, Me (Q1; Q3) | 8.37 (5.0; 13.0) | 15.3 (10.8; 24.7) | 15.5 (12.5; 17.8) | 0.003 | MFI nCD64 > 10 (count/all) | 7/20 (35%) | 12/16 (75%) | 9/10 (90%) | 0.004 | DOR (±95% CI) | | 5.5 (1.3; 23.9) | 16.7 (1.7; 160) | | Sensitivity, % | | 75 | 90 | | Specificity, % | | 65 | 65 | | Positive predictive value (PPV), % | | 63.2 | 56.3 | | Negative predictive value (NPV), % | | 76.5 | 92.9 | | Index CD64, Me (Q1; Q3) | 3.07 (1.94; 6.3) | 11.05 (7.7; 19.45) | 7.2 (6.7; 10.4) | 0.002 | Index CD64 > 4 (count/all) | 7/20 (35%) | 14/16 (88%) | 9/10 (90%) | <0.001 | DOR | | 13.0 (2.2; 74.3) | 16.7 (1.7; 160) | | Sensitivity, % | | 87.5 | 90 | | Specificity, % | | 65 | 65 | | Positive predictive value (PPV), % | | 66.6 | 56.3 | | Negative predictive value (NPV), % | | 86.6 | 92.86 | | HLA-DR + Mon, Me (Q1; Q3) | 95 (79.0; 98.0) | 88.0 (80; 98) | 88 (75.0; 90.0) | >0.05 | MFI monHLA-DR, Me (Q1; Q3) | 3.59 (2.38; 7.5) | 5.2 (2.59; 6.7) | 2.1 (1.63; 2.9) | 0.015 | HLA-DR + lymph, Me (Q1; Q3) | 5.7 (4.5; 8.6) | 5.16 (3.0; 6.6) | 9.82 (3.72; 16.94) | >0.05 | MFI lymphHLA-DR, Me (Q1; Q3) | 9.7 (8.2; 23.0) | 16.1 (13.7; 17.7) | 11.6 (6.7; 12.5) | 0.008 | CD25 + CD4+, Me (Q1; Q3) | 16.0 (6.96; 14.75) | 25.5 (10.0; 55.00) | 17.0 (12.25; 38.25) | >0.05 | Statistically significant p values are in bold. | P value, Kruskal–Wallis test for comparing 3 groups. |
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