Research Article

Influence of Pathogen Type on Neonatal Sepsis Biomarkers

Table 4

Activation markers.

ParameterControlGram-positive bacteremiaGram-negative bacteremiaP value

MFI nCD24, Me (Q1; Q3)9.9 (7.48; 14.1)7.16 (4.44; 15.12)8.02 (7.48; 20.9)>0.05
MFI nCD64, Me (Q1; Q3)8.37 (5.0; 13.0)15.3 (10.8; 24.7)15.5 (12.5; 17.8)0.003
MFI nCD64 > 10 (count/all)7/20 (35%)12/16 (75%)9/10 (90%)0.004
DOR (±95% CI)5.5 (1.3; 23.9)16.7 (1.7; 160)
Sensitivity, %7590
Specificity, %6565
Positive predictive value (PPV), %63.256.3
Negative predictive value (NPV), %76.592.9
Index CD64, Me (Q1; Q3)3.07 (1.94; 6.3)11.05 (7.7; 19.45)7.2 (6.7; 10.4)0.002
Index CD64 > 4 (count/all)7/20 (35%)14/16 (88%)9/10 (90%)<0.001
DOR13.0 (2.2; 74.3)16.7 (1.7; 160)
Sensitivity, %87.590
Specificity, %6565
Positive predictive value (PPV), %66.656.3
Negative predictive value (NPV), %86.692.86
HLA-DR + Mon, Me (Q1; Q3)95 (79.0; 98.0)88.0 (80; 98)88 (75.0; 90.0)>0.05
MFI monHLA-DR, Me (Q1; Q3)3.59 (2.38; 7.5)5.2 (2.59; 6.7)2.1 (1.63; 2.9)0.015
HLA-DR + lymph, Me (Q1; Q3)5.7 (4.5; 8.6)5.16 (3.0; 6.6)9.82 (3.72; 16.94)>0.05
MFI lymphHLA-DR, Me (Q1; Q3)9.7 (8.2; 23.0)16.1 (13.7; 17.7)11.6 (6.7; 12.5)0.008
CD25 + CD4+, Me (Q1; Q3)16.0 (6.96; 14.75)25.5 (10.0; 55.00)17.0 (12.25; 38.25)>0.05
Statistically significant p values are in bold.
P value, Kruskal–Wallis test for comparing 3 groups.