Research Article

Therapeutic Benefit in Rheumatoid Cachexia Illustrated Using a Novel Primary Human Triple Cell Coculture Model

Figure 8

Triple culture supernatant extracellular matrix factor concentrations comparing healthy (NC), RA treatment-naïve (RATN), and RA treatment-nonresponding (RATNR) patients. (a) TGFβ; (b) decorin; (c) fibronectin; (d) collagen 1a1; (e) collagen IV. Statistical analysis: one-way ANOVA (parametric: (a, b, c, d) or Kruskal–Wallis test (nonparametric: e). ; ; . n = 6 per group. Data represented as mean ± SD. TGFβ = transforming growth factor-β; BMP-7 = bone morphogenetic protein 7.
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