Therapeutic Benefit in Rheumatoid Cachexia Illustrated Using a Novel Primary Human Triple Cell Coculture Model

Table 1

Comparison of the concentrations of cytokines and growth factors in the triple coculture exposed to NC patient serum after being treated with placebo or BMP-7. Data represented as mean ± SD. . n = 6 per group. TNF-α = tumour necrosis factor-α; IL = interleukin; HGF = hepatocyte growth factor; TGF-β = transforming growth factor-β.

Treatment	Nonarthritic control (NC)
	Placebo	BMP-7
TNF-α (pg/ml)	18.52 ± 2.0	17.15 ± 1.5
IL-6 (pg/ml)	5561 ± 1122.8	5710 ± 1227.4
HGF (pg/ml)	201.6 ± 25.8	189.4 ± 20.7
Follistatin (pg/ml)	651.3 ± 79.3	625.2 ± 84.9
Myostatin (pg/ml)	1478 ± 631.0	1381 ± 319.5
TGF-β (pg/ml)	12017 ± 1478	10423 ± 1198
Decorin (ng/ml)	5.68 ± 2.17	5.90 ± 2.38
Fibronectin (ng/ml)	36633 ± 10883	19408 ± 7173
Collagen IV (ng/ml)	13.20 ± 3.71	21.89 ± 9.30