NPT1220-312, a TLR2/TLR9 Small Molecule Antagonist, Inhibits Pro-Inflammatory Signaling, Cytokine Release, and NLRP3 Inflammasome Activation

Figure 6

NPT1220-312 blocks Pam₃CSK₄-evoked cytokine release in whole blood. NPT1220-312 blocked: (a) Pam₃CSK₄-evoked release of: IL-6; (b) murine IL-8 homologues: KC; and (c) MIP-2 in murine whole blood. NPT1220-312 blocked: (d) Pam₃CSK₄-evoked release of: IL-6 and (e) IL-8 in human whole blood.

(a)

(b)

(c)

(d)

(e)