NPT1220-312, a TLR2/TLR9 Small Molecule Antagonist, Inhibits Pro-Inflammatory Signaling, Cytokine Release, and NLRP3 Inflammasome Activation

<table class="table-group" id="tab1"><tr><td><table class="table"><tr><td class="thead-hr" colspan="3"><hr/></td></tr><tr class="thead"><td class="align_left">Inhibitor</td><td class="align_center">IC<sub>50</sub> (PAM-2; μM)</td><td class="align_center">IC<sub>50</sub> (PAM-3; μM)</td></tr><tr><td class="thead-hr" colspan="3"><hr/></td></tr><tr><td class="align_left">NPT1220-312</td><td class="align_center">0.7</td><td class="align_center">0.5</td></tr><tr><td class="align_left">C29</td><td class="align_center">57.6</td><td class="align_center">44.4</td></tr><tr><td class="align_left">O-vanillin</td><td class="align_center">61.6</td><td class="align_center">40.2</td></tr><tr><td class="align_left">CU-CPT22</td><td class="align_center">38.9</td><td class="align_center">28.6</td></tr><tr class="table-tr"><td colspan="3"><hr class="tbody-hr"/></td></tr></table></td></tr></table>

<div>Potencies of NPT1220-312 and other reference inhibitors of TLR2.</div>

International Journal of Inflammation

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Table 1

Table 1: NPT1220-312, a TLR2/TLR9 Small Molecule Antagonist, Inhibits Pro-Inflammatory Signaling, Cytokine Release, and NLRP3 Inflammasome Activation 

Table 1 | NPT1220-312, a TLR2/TLR9 Small Molecule Antagonist, Inhibits Pro-Inflammatory Signaling, Cytokine Release, and NLRP3 Inflammasome Activation 