Causal Biological Network Model for Inflammasome Signaling Applied for Interpreting Transcriptomic Changes in Various Inflammatory States

Figure 3

Part of the inflammasome network model scored with transcriptomic data from GSE2737. The bar graph above each node, which was scored, shows the inferred fold change in the (1) unaffected and (2) affected skin areas of psoriatic patients relative to the skin of healthy controls. The directionalities are shown as yellow or blue bars for inferred upregulation or downregulation, respectively. The black outline refers to nodes that were significantly impacted in both samples, the blue outline refers to nodes that were significantly impacted only in unaffected skin samples, and the purple outline refers to nodes that were significantly impacted only in affected skin samples.