Causal Biological Network Model for Inflammasome Signaling Applied for Interpreting Transcriptomic Changes in Various Inflammatory States

Figure 4

Part of the inflammasome network model scored with transcriptomic data from E-MEXP-839. The bar graph above each node, which was scored, shows the inferred fold change in the liver tissue of (1) 16-, (2) 96-, and (3) 130-week-old wild-type (WT) mice relative to 8-week-old WT mice. The directionalities are shown as yellow or blue bars for inferred upregulation or downregulation, respectively. The black outline refers to nodes that were significantly impacted in all ages, the purple outline refers to nodes that were significantly impacted at two time points, and the blue outline refers to nodes that were significantly impacted at only one time point.