Mortality Associated with Recurrent Extreme Hyperferritinemia in Critically Ill Adolescents

Table 1

Epidemiologic data for 4 critically ill adolescents with recurrent extreme hyperferritinemia.

	Patient	Patient	Patient	Patient
Age (years)	15	16	16	19
Gender	Female	Male	Male	Female
Underlying disease	Aplastic anemia	Crohn’s disease, histiocytic sarcoma	X-linked inhibitor of apoptosis deficiency	Mixed phenotype acute leukemia
COVID-19 infection	Yes	No	Yes	No
HSCT	Yes	No	Yes	No
Inflammation	CSS	HLH	HLH	CSS
Immunosuppression	Lymphocytopenia and neutropenia	Lymphocytopenia	Lymphocytopenia and neutropenia	Lymphocytopenia and neutropenia
Nutritional state	Cachexia	Cachexia	Cachexia	Cachexia
First peak in ferritin (ng/mL)/HD	11,856/79	16,809/3	30,164/15	25,108/9
Last peak in ferritin (ng/mL)/HD	22,360/175	36,617/22	>100,000/	36,241/69
Peak in IL-6 (pg/mL)/HD	1,423/178	>4,200/	36,115/99	12,376/67
Peak in CRP (mg/L)/HD	120/97	117/1	NA	>300/
Peak in D-dimer (microg/mL)/HD	11.31/114	17.48/4	>20/	3.77/16

The peak for this biomarker was noted on several different days for this patient. CRP: C-reactive protein, CSS: cytokine storm syndrome, HLH: hemophagocytic lymphohistiocytosis, HD: hospital day, HSCT: hematopoietic stem cell transplant, and NA: not available.