The Restoring Effect of Human Umbilical Cord-Derived Mesenchymal Cell-Conditioned Medium (hMSC-CM) against Carbon Tetrachloride-Induced Pulmonary Fibrosis in Male Wistar Rats

<div>The results of the protein and gene expressions of LOX, TNF-<i>α</i>, and TGF-<i>β</i>1 in the lung tissue of studied animals. (a) Level expressions of lysyl oxidase (LOX) gene, (b) level expressions of tumor necrosis factor-alpha (TNF-<i>α</i>) gene, (c) level expressions of transforming growth factor-<i>β</i>1 (TGF-<i>β</i>1) gene. (d) Level expressions of LOX protein. (e) Level expressions of TNF-<i>α</i> protein, (f) level expressions of TGF-<i>β</i>1 protein. C: control group; C.O: olive oil control group. C.Ms: hMSC-CM control group, Fb: fibrosis group, Fb.Ms: group Fb with hMSC-CM treatment. 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103S58 78 58 46C58 11 82 -12 113 -12Z"></path></g><g transform="matrix(.013,0,0,-0.013,31.809,0)"><path d="M241 635C89 635 35 457 35 312C35 153 89 -12 240 -12C390 -12 443 166 443 312C443 466 390 635 241 635ZM238 602C329 602 354 454 354 312C354 172 330 22 240 22C152 22 124 173 124 313S148 602 238 602Z"></path></g><g transform="matrix(.013,0,0,-0.013,38.049,0)"><path d="M241 635C89 635 35 457 35 312C35 153 89 -12 240 -12C390 -12 443 166 443 312C443 466 390 635 241 635ZM238 602C329 602 354 454 354 312C354 172 330 22 240 22C152 22 124 173 124 313S148 602 238 602Z"></path></g><g transform="matrix(.013,0,0,-0.013,44.289,0)"><path d="M384 0V27C293 34 287 42 287 114V635C232 613 172 594 109 583V559L157 557C201 555 205 550 205 499V114C205 42 199 34 109 27V0H384Z"></path></g></svg>).</span> <sup>a</sup>Significantly different from C. <sup>b</sup>Significantly different from C.O. <sup>c</sup>Significantly different from C.Ms. <sup>d</sup>Significantly different from that of Fb.</div>

International Journal of Inflammation

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Figure 4

Figure 4: The Restoring Effect of Human Umbilical Cord-Derived Mesenchymal Cell-Conditioned Medium (hMSC-CM) against Carbon Tetrachloride-Induced Pulmonary Fibrosis in Male Wistar Rats 

Figure 4 | The Restoring Effect of Human Umbilical Cord-Derived Mesenchymal Cell-Conditioned Medium (hMSC-CM) against Carbon Tetrachloride-Induced Pulmonary Fibrosis in Male Wistar Rats 