International Journal of Inflammation

Microbiota in Chronic Mucosal Inflammation


Publishing date
01 Oct 2010
Status
Published
Submission deadline
01 Apr 2010

Lead Editor

1Department of Internal Medicine, Division of Gastroenterology and Hepatology, 8091 Zurich, Switerland

2Biofunctionality Unit, ZIEL Research Center for Nutrition and Food Science, Center for Dient and Disease (CDD), Technische Universität München, Freising - Weihenstephan, Germany

3School of Medicine, Division of Digestive Diseases and Nutrition,The University of North Carolina, Greenville, NC, USA


Microbiota in Chronic Mucosal Inflammation

Description

The barrier function of the intestinal mucosa is crucial for the prevention of an invasion of bacteria of the gut microbiota into the human body. Subsequently, an intact barrier is of great importance for the prevention of permanent and chronic inflammation as a reaction to the commensal intestinal flora. The mucosal innate immune system has developed effective defense mechanisms against microbial attacks. Local inflammation that is always present to some limited extent can be regarded as one component of the mucosal defense system. Immediate recognition of bacteria by pattern recognition receptors and lysis of bacteria in (auto)phagosomes are crucial for these functions. It is obvious that the mechanisms initiating or limiting inflammation need to be tightly regulated as they themselves might alter the mechanical barrier function Nod2 variants that have been identified to be a susceptibility factor for Crohn's disease. The Nod2 protein is an intracellular sensor of the bacterial wall product muramyl dipeptide (MDP) and activates the transcription factor NF-kappaB upon MDP binding. A reduced expression of defensins (endogenous antibiotics) has been found in patients with Crohn's disease and ulcerative colitis especially when Nod2 variants are present. We particularly take an interest in manuscripts focusing on recent advances in basic mechanisms of how the bacteria contribute to mucosal inflammation as well as how bacterial induction of mucosal inflammation contributes to human disease. Papers that focus on mechanisms of tolerance induction against the commensal flora would be of great interest. In addition, signal transduction pathways induced in the mucosa by the gut microbiota should be reviewed. Microbial factors regulating experimental and human colitis should be highlighted.

Main topics include, but are not limited to:

  • Regulation of colitis by bacterial DNA and bacterial wall components
  • Bacteria induced apoptosis of intestinal epithelial
  • Autophagy and pattern recognition receptors in mucosal inflammation
  • Nod2 and bacterial recognition as a control system for mucosal inflammation
  • T-bet, regulatory T-cells, and host-commensal relationships
  • How bacterial induction of mucosal inflammation contributes to human disease
  • Changes of the mucosa microbiota during chronic inflammation
  • Defensins, bacteria, and mucosal defence in inflammatory bowel disease
  • Traditional and opportunistic pathogens in inflammatory bowel disease

Before submission authors should carefully read over the journal's Author Guidelines, which are located at http://www.hindawi.com/journals/iji/guidelines/. Prospective authors should submit an electronic copy of their complete manuscript through the journal Manuscript Tracking System at http://mts.hindawi.com/ according to the following timetable:


Articles

  • Special Issue
  • - Volume 2010
  • - Article ID 395032
  • - Editorial

Microbiota in Chronic Mucosal Inflammation

G. Gerhard Rogler | Dirk Haller | Christian Jobin
  • Special Issue
  • - Volume 2010
  • - Article ID 910283
  • - Review Article

Antimicrobial Peptides in Gastrointestinal Inflammation

Simon Jäger | Eduard F. Stange | Jan Wehkamp
  • Special Issue
  • - Volume 2010
  • - Article ID 894972
  • - Research Article

Suppression of Tumorigenesis: Modulation of Inflammatory Cytokines by Oral Administration of Microencapsulated Probiotic Yogurt Formulation

Aleksandra Malgorzata Urbanska | Arghya Paul | ... | Satya Prakash
  • Special Issue
  • - Volume 2010
  • - Article ID 814326
  • - Review Article

The Role of Bacteria and Pattern Recognition Receptors in GvHD

E. Holler | K. Landfried | ... | G. Rogler
  • Special Issue
  • - Volume 2010
  • - Article ID 321426
  • - Review Article

The Interaction of Large Bowel Microflora with the Colonic Mucus Barrier

Jeffrey P. Pearson | Iain A. Brownlee
  • Special Issue
  • - Volume 2010
  • - Article ID 386956
  • - Review Article

Intestinal Host-Microbe Interactions under Physiological and Pathological Conditions

Rodrigo Bibiloni | Eduardo J. Schiffrin
  • Special Issue
  • - Volume 2010
  • - Article ID 823710
  • - Review Article

Peyer's Patches: The Immune Sensors of the Intestine

Camille Jung | Jean-Pierre Hugot | Frédérick Barreau
  • Special Issue
  • - Volume 2010
  • - Article ID 641910
  • - Review Article

Inflammatory Bowel Diseases: When Natural Friends Turn into Enemies—The Importance of CpG Motifs of Bacterial DNA in Intestinal Homeostasis and Chronic Intestinal Inflammation

Florian Obermeier | Claudia Hofmann | Werner Falk
  • Special Issue
  • - Volume 2010
  • - Article ID 954051
  • - Review Article

The Bowel Microbiota and Inflammatory Bowel Diseases

Gerald W. Tannock
  • Special Issue
  • - Volume 2010
  • - Article ID 986046
  • - Research Article

A Strong Impact of Genetic Background on Gut Microflora in Mice

R. Steven Esworthy | David D. Smith | Fong-Fong Chu
International Journal of Inflammation
 Journal metrics
Acceptance rate13%
Submission to final decision64 days
Acceptance to publication36 days
CiteScore5.500
Impact Factor-
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