International Journal of Inflammation

Adult Onset Still's Disease and Autoinflammation


Publishing date
17 Aug 2012
Status
Published
Submission deadline
17 Feb 2012

1Lincoln Medical & Mental Health Center; Division of Rheumatology, Weill Cornell Medical College, Cornell University, New York, NY 10021, USA

2Department of Rheumatology, Hospital Pitié-Salpétrière, 47-83 Boulevard de l'Hôpital, 75013 Paris, France

3Department of Experimental Physiology, School of Medicine, University of Athens, Athens, Greece

4Regeneron; Rockefeller University, New York, NY, USA

5Robert Wood Johnson Medical School, UMDNJ, New Brunswick, NJ, USA


Adult Onset Still's Disease and Autoinflammation

Description

Adult Onset Still's Disease (AOSD) is a rare systemic inflammatory disease characterized by fever, rash, and arthritis. The exact pathogenesis and etiologic factors responsible for the clinical features remain to be determined. Recent immunological research has been carried out to evolve the well-documented role of systemic inflammation and immunoregulatory abnormalities by implicating the inflammasome into the disease pathogenesis. Laboratory abnormalities that are nonspecific but may be indicative of the disease include leukocytosis, elevation of ferritin, and other acute phase reactants. Diagnosis is basically clinical and requires exclusion of infection, malignancy, or other rheumatic disorders. The mainstay therapy initially involves corticosteroids and methotrexate irrespectively of the disease pattern. In refractory cases, biologic agents like anti-TNF, anti-IL1, and anti-IL6 have been used with promising results.

We invite authors to submit original research articles and review articles describing the complex pathophysiology, protean clinical manifestations, and current and emerging therapies for AOSD. Manuscripts on the closely related juvenile disease form, that is, systemic onset Juvenile Idiopathic Arthritis (soJIA) will also be considered. Potential topics include, but are not limited to:

  • The pathophysiology of the autoinflammatory diseases, where AOSD belongs, including data on the following:
    • The regulation of the inflammasome
    • The interplay of Th1/Th17 immunity and cytokine biology
  • The epidemiology of AOSD
  • The diverse clinical manifestations and complications of AOSD and any form of therapy for AOSD including medications targeting specific organs/symptoms
  • The overall AOSD prognosis in terms of morbidity and mortality
  • The available disease modifying therapies including immunomodulatory treatments and/or biologic therapies
  • The potential evolution of therapies based on preclinical, clinical, or translational studies related to new therapies for AOSD

Manuscripts may also focus on the diverse clinical manifestations of AOSD and any form of therapy for AOSD including medications targeting specific organs/symptoms; disease modifying therapies; immunomodulatory treatments; and/or biologic therapies. Manuscripts can describe preclinical or clinical studies related to new therapies for AOSD.

Articles published in this special issue will not be subject to the journal's Article Processing Charges.

Before submission authors should carefully read over the journal's Author Guidelines, which are located at http://www.hindawi.com/journals/iji/guidelines/. Prospective authors should submit an electronic copy of their complete manuscript through the journal Manuscript Tracking System at http://mts.hindawi.com/ according to the following timetable:


Articles

  • Special Issue
  • - Volume 2012
  • - Article ID 964751
  • - Editorial

Adult Onset Still's Disease and Autoinflammation

Petros Efthimiou | L. Nandini Moorthy | ... | Bruno Fautrel
  • Special Issue
  • - Volume 2012
  • - Article ID 879020
  • - Review Article

Adult-Onset Still’s Disease: From Pathophysiology to Targeted Therapies

Clio P. Mavragani | Evangelos G. Spyridakis | Michael Koutsilieris
  • Special Issue
  • - Volume 2012
  • - Article ID 156890
  • - Clinical Study

IL-18 Serum Level in Adult Onset Still’s Disease: A Marker of Disease Activity

Serena Colafrancesco | Roberta Priori | ... | Guido Valesini
  • Special Issue
  • - Volume 2012
  • - Article ID 317820
  • - Review Article

Anti-Interleukin-1 Agents in Adult Onset Still's Disease

Cecilia Giampietro | Bruno Fautrel
  • Special Issue
  • - Volume 2012
  • - Article ID 480373
  • - Review Article

Is Still's Disease an Autoinflammatory Syndrome?

Linda Rossi-Semerano | Isabelle Koné-Paut
  • Special Issue
  • - Volume 2012
  • - Article ID 298405
  • - Review Article

Ferritin in Adult-Onset Still’s Disease: Just a Useful Innocent Bystander?

Bella Mehta | Petros Efthimiou
  • Special Issue
  • - Volume 2012
  • - Article ID 271569
  • - Review Article

Systemic Arthritis in Children: A Review of Clinical Presentation and Treatment

R. Gurion | T. J. A. Lehman | L. N. Moorthy
  • Special Issue
  • - Volume 2012
  • - Article ID 819467
  • - Review Article

Th17 Response and Inflammatory Autoimmune Diseases

Janelle C. Waite | Dimitris Skokos
International Journal of Inflammation
 Journal metrics
Acceptance rate13%
Submission to final decision64 days
Acceptance to publication36 days
CiteScore5.500
Impact Factor-
 Submit

We are committed to sharing findings related to COVID-19 as quickly as possible. We will be providing unlimited waivers of publication charges for accepted research articles as well as case reports and case series related to COVID-19. Review articles are excluded from this waiver policy. Sign up here as a reviewer to help fast-track new submissions.