Table of Contents
International Journal of Inorganic Chemistry
Volume 2010 (2010), Article ID 975756, 7 pages
http://dx.doi.org/10.1155/2010/975756
Research Article

Reaction of the Anticancer Organometallic Ruthenium Compound, [(-Cymene)Ru(ATSC)Cl] with Human Serum Albumin

Science Division, Lyon College, 2300 Highland Road, Batesville, AR 72501, USA

Received 8 September 2009; Accepted 6 November 2009

Academic Editor: Stephen Ralph

Copyright © 2010 Floyd A. Beckford. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

The reaction of [(--cymene)Ru(ATSC)Cl] (ATSC -anthraldehyde thiosemicarbazone) with human serum albumin was investigated at different temperatures using fluorescence and infrared spectrophotometry. The binding constant, K, for the reaction was determined using a number of different methods. Using a modified Stern-Volmer equation, K was determined to be and at 293 K, 298 K, and 308 K, respectively. A thermodynamic analysis showed that the reaction is spontaneous with G being negative. The enthalpy of reaction  kJ and the entropy of reaction . The values of and suggest that hydrophobic forces are dominant in the mode of interaction and that the process is mostly entropy driven.