International Journal of Inorganic Chemistry / 2011 / Article / Fig 5

Research Article

Insights into DNA Platination within Unusual Structural Settings

Figure 5

Evolution of the reaction profile for I, cis-[Pt(15NH3)2I2] with the tandem sheared GA mismatch DNA duplex d(GCGAGC)2 recorded as a function of time based on integration of 2D [1H, 15N] HSQC NMR data acquired at a magnetic field strength of 14.1 T (1H = 600 MHz). Key: blue diamond: cis-[Pt(15NH3)2I2] starting material; red square: cis-[Pt(15NH3)2I(OH2)]+ monoaqua, monoiodo adduct; green triangle: minor cis-[Pt(15NH3)2I,O]+ monoiodo, mono-“O” adduct; cyan cross: major cis-[Pt(15NH3)2I,N]+ intermediate; violet circle: cis-[Pt(15NH3)2N,N]2+ reaction end product.

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