Inhibition of RNA Helicases of ssRNA⁺ Virus Belonging to Flaviviridae, Coronaviridae and Picornaviridae Families

Table 1

Viral helicases of same ssRNA⁺ Viruses (belonging to Flaviviridae, Coronaviridae, and Picornaviridae families) [9, 10, 33].

Family	Species	Helicase family	Helicase name	IN VITRO activity
Flaviviridae	Yellow fever virus	SF2	NS3	RNA stimulated NTPase
	West Nile virus	SF2	NS3	RTPase 3′–5′ helicase
	Dengue fever virus	SF2	NS3	3′–5′RNA helicase RTPase
	Japanese encephalitis virus	SF2	NS3	3′–5′RNA helicase
	Bovine viral diarrhea virus	SF2	NS3	3′–5′RNA helicase
	Hepatitis C virus	SF2	NS3	3′–5′RNA /DNA helicase
	Hepatitis G virus	SF2	NS3	3′–5′RNA /DNA helicase
	Hepatitis A virus	SF3	2C	NTPase
Coronaviridae	Human coronavirus 229E	SF1	Nsp 13	3′–5′RNA/DNA helicase RTPase
	SARS Coronavirus	SF1	Nsp 13	3′–5′RNA/DNA helicase RTPase
Picornaviridae	Poliovirus	SF3	2C	NTPase
	Rhinovirus	SF3	2C	NTPase