Table 1: Dopamine receptor family.

D1 subfamilyD2 subfamily
D1 (MIM: 126449)
(Gene ID: 1812)
D5 (MIM: 126453)
(Gene ID: 1816)
D2 (MIM: 126450)
(Gene ID: 1813)
D3 (MIM: 126451)
(Gene ID: 1814)
D4 (MIM: 126452)
(Gene ID: 1815)

Locus (human)5q35.14p16.111q233q13.311p15.5

Amino acids
Molecular weight
446
49, 162
477
52,820
443 (D2L)/414 (D2S)
50, 489/47,216
400
44,064
419
43,771
G-protein couplingGαs, GαolfGαs, GαqGαi, Gαo, GβγGαi, Gαo, GβγGαi, Gαo, Gβγ

Signaling moleculesAC, cAMP, PKA, DARPP-32, ERK, MEK GIRK?PLC, PKC, IP3AC, cAMP, PKA, DARPP-32
L/N-type calcium channel
GIRK
β-arrestin2, Akt, GSK-3 (D2, D3)

LocalizationStriatum
Nucleus accumbens
Olfactory bulb
Substantia nigra
Amygdala
Cortex
Hippocampus
Cortex
Substantia nigra
Hypothalamus
Hippocampus
Striatum
Nucleus accumbens
Ventral tegmental area
Substantia nigra
Olfactory bulb
Olfactory bulb
Nucleus accumbens Striatum
Substantia nigra
Hippocampus
Hypothalamus
Frontal cortex
Amygdala
Hypothalamus
Mesencephalon
Nucleus accumbens.

Selective agonistsSKF-38393
SKF-81297
Fenoldopam (SKF-82526)
Bromocriptine
Pergolide
Cabergoline
Ropinirole
7-OH-DPAT
Pramipexole
Rotigotine
PD-128907
A-412997
ABT-670
PD-168077

Selective antagonistsSCH-23390
SCH-39166
SKF-83566
Haloperidol
Raclopride
Sulpiride
Spiperone
Risperidone
Nafadotride
GR-103691
GR-218231
SB-277011A
NGB-2904
PG-01037
ABT-127
A-381393
FAUC213
L-745870
L-750667

Abbreviations: AC, adenylatecyclase; cAMP, cyclic AMP; PKA, protein kinase A; DARPP-32, 32-kDa DA and cAMP-regulated phosphoprotein; ERK, extracellular signal-regulated kinase; MEK, mitogen-activated protein/ERK kinase; GIRK, G protein-coupled inwardly rectifying potassium channels; PLC, phospholipase C; PKC, protein kinase C; IP3, inositol triphosphate; GSK-3, glycogen synthase kinase 3; 7-OH-DPAT, 7-hydroxy-N,N-dipropyl-2-aminotetralin.
This table is complied from information in several review reports and articles [1217]. Data of amino acids and molecular weight of each receptor are referred from NCBI, build 37.2 (D1; NP_000785.1, D2L; NP_000786.1, D2S; NP_057658.2, D3; NP_000787.2, D4; NP_000788.2, D5; NP_000789.1).