| | D1 subfamily | | D2 subfamily | | | | D1 (MIM: 126449) (Gene ID: 1812) | D5 (MIM: 126453) (Gene ID: 1816) | D2 (MIM: 126450) (Gene ID: 1813) | D3 (MIM: 126451) (Gene ID: 1814) | D4 (MIM: 126452) (Gene ID: 1815) |
| Locus (human) | 5q35.1 | 4p16.1 | 11q23 | 3q13.3 | 11p15.5 |
| Amino acids Molecular weight | 446 49, 162 | 477 52,820 | 443 (D2L)/414 (D2S) 50, 489/47,216 | 400 44,064 | 419 43,771 | G-protein coupling | Gαs, Gαolf | Gαs, Gαq | Gαi, Gαo, Gβγ | Gαi, Gαo, Gβγ | Gαi, Gαo, Gβγ |
| Signaling molecules | AC↑, cAMP, PKA, DARPP-32, ERK, MEK GIRK? | PLC, PKC, IP3 | AC↓, cAMP, PKA, DARPP-32 | L/N-type calcium channel | GIRK | β-arrestin2, Akt, GSK-3 (D2, D3) |
| Localization | Striatum Nucleus accumbens Olfactory bulb Substantia nigra Amygdala Cortex Hippocampus | Cortex Substantia nigra Hypothalamus Hippocampus | Striatum Nucleus accumbens Ventral tegmental area Substantia nigra Olfactory bulb | Olfactory bulb Nucleus accumbens Striatum Substantia nigra Hippocampus Hypothalamus | Frontal cortex Amygdala Hypothalamus Mesencephalon Nucleus accumbens. |
| Selective agonists | SKF-38393 SKF-81297 Fenoldopam (SKF-82526) | — | Bromocriptine Pergolide Cabergoline Ropinirole | 7-OH-DPAT Pramipexole Rotigotine PD-128907 | A-412997 ABT-670 PD-168077 |
| Selective antagonists | SCH-23390 SCH-39166 SKF-83566 | — | Haloperidol Raclopride Sulpiride Spiperone Risperidone | Nafadotride GR-103691 GR-218231 SB-277011A NGB-2904 PG-01037 ABT-127 | A-381393 FAUC213 L-745870 L-750667 |
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Abbreviations: AC, adenylatecyclase; cAMP, cyclic AMP; PKA, protein kinase A; DARPP-32, 32-kDa DA and cAMP-regulated phosphoprotein; ERK, extracellular signal-regulated kinase; MEK, mitogen-activated protein/ERK kinase; GIRK, G protein-coupled inwardly rectifying potassium channels; PLC, phospholipase C; PKC, protein kinase C; IP3, inositol triphosphate; GSK-3, glycogen synthase kinase 3; 7-OH-DPAT, 7-hydroxy-N,N-dipropyl-2-aminotetralin. This table is complied from information in several review reports and articles [12–17]. Data of amino acids and molecular weight of each receptor are referred from NCBI, build 37.2 (D1; NP_000785.1, D2L; NP_000786.1, D2S; NP_057658.2, D3; NP_000787.2, D4; NP_000788.2, D5; NP_000789.1).
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