Evaluation of a Set of C9 N-acyl Neu5Ac2en Mimetics as Viral Sialidase Selective Inhibitors

Figure 3

The multiple-sequence alignments of sialidase protein of viral strains (H1N1 [AcqP03468], H3N2 [AcqP03475], and H5N3 [AcqA6YJ51]) and H1N1 (3B7E). Identical and similar residues are shown on a dark green and a light green background, respectively. The active site amino acid residues corresponding to the active site of 3B7E are shown in bold. Amino acid residues interacting with C9 substituent of compound 8 in the active site model of H1N1 (3B7E) are indicated in red. Amino acid differences in the viral sialidases corresponding to the residue Ser246 (3B7E) and its vicinity are underlined.