Journals
Publish with us
Publishing partnerships
About us
Blog
International Journal of Medicinal Chemistry
Table of Contents
Special Issues
International Journal of Medicinal Chemistry
/
2011
/
Article
/
Tab 1
/
Research Article
Synthesis, Molecular Modeling, and Biological Evaluation of Novel Tetrahydro-
β
-Carboline Hydantoin and Tetrahydro-
β
-Carboline Thiohydantoin Derivatives as Phosphodiesterase 5 Inhibitors
Table 1
Inhibitory effect of the synthesized compounds on PDE5.
Cpd #
%PDE5 inhibition at 10
μ
M
PDE5 inhibition IC
50
μ
M
Cpd
%PDE5 inhibition at 10
μ
M
PDE5 inhibition IC
50
μ
M
1
77
2.5
11
46
ND
2
63
ND
12
87
0.55
3
55
ND
13
63
ND
4
75
6.4
14
60
ND
5
87
0.36
15
35
ND
6
88
0.72
16
63
ND
7
54
ND
17
29
ND
8
97
0.36
18
23
ND
9
83
2.4
19
87
0.56
10
68
ND
20
58
ND
Tadalafil
99
0.004