International Journal of Medicinal Chemistry / 2011 / Article / Tab 1

Research Article

Synthesis, Molecular Modeling, and Biological Evaluation of Novel Tetrahydro-β-Carboline Hydantoin and Tetrahydro-β-Carboline Thiohydantoin Derivatives as Phosphodiesterase 5 Inhibitors

Table 1

Inhibitory effect of the synthesized compounds on PDE5.

Cpd #%PDE5 inhibition at 10 μMPDE5 inhibition IC50μMCpd %PDE5 inhibition at 10 μMPDE5 inhibition IC50μM

1772.51146ND
263ND12870.55
355ND1363ND
4756.41460ND
5870.361535ND
6880.721663ND
754ND1729ND
8970.361823ND
9832.419870.56
1068ND2058ND
Tadalafil990.004

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