Studies on 16α-Hydroxylation of Steroid Molecules and Regioselective Binding Mode in Homology-Modeled Cytochrome P450-2C11

Figure 1

The sequence alignment among CYP2C11(Swiss-prot entry code: P08683), and chain A of warfarin-bound CYP2C9 (PDB code:1og5), CYP2C9 (PDB code:1og2), flurbiprofen-bound CYP2C9 (PDB code:1r9o). The first 29, 29, 29, and 25 amino acids of these proteins, respectively, are not shown and were not modeled. Residues of target CYP2C11 are highlighted in bold letters, the amino acids of the binding site are indicated by boxed text, the nonmatched amino acids are underlined, the identical key amino acid residues of 1rgo with that of CYP2C11 are shown in bold Arial black letters, and the amino acid sequences of chain B of 1og5 and 1og2 were deleted due to their identical amino acid composition to their chain A.