Syntheses and Biological Activity of Some Derivatives of C-9154 Antibiotic

Table 2

Zones of inhibition (mm) of the analogue and derivatives.

	IA/01/1	IA/24/1/B	IA/21/1/B	IA/22/1/B	IA/23/1/B	IA/19/1/B	IA/20/1/B	DMSO	Sparfloxacin	Fluconazole
	(10 μg/mL)	(5 μg/mL)	(5 μg/mL)	(5 μg/mL)	(5 μg/mL)	(5 μg/mL)	(5 μg/mL)		(20 μg/mL)	(50 μg/mL)
MRSA	20	32	29	35	32	34	31	0	22	0
S. aureus	28	30	32	30	32	31	32	0	27	0
S. pyogenes	24	0	30	37	36	0	29	0	24	0
B. subtilis	30	26	32	32	30	29	31	0	30	0
C. ulcerans	0	30	29	27	30	0	27	0	0	0
E. coli	27	27	29	22	25	29	27	0	27	0
P. mirabilis	22	25	27	27	24	31	26	0	22	0
P. aeruginosa	0	0	0	0	0	0	0	0	20	0
S. typhii	26	30	27	29	31	29	22	0	21	0
S. dysenteriae	24	27	27	35	32	31	24	0	27	0
K. pneumoniae	27	24	27	30	31	29	27	0	25	0
C. albicans	22	22	24	27	30	24	21	0	0	24
A. nigre	21	0	0	0	0	0	0	0	0	0
T. rubrum	0	0	0	0	0	0	0	0	0	20