Review Article
Development of 5-Substituted N-Methylmorphinan-6-ones as Potent Opioid Analgesics with Improved Side-Effect Profile
Table 3
Overview of the analgesic activity of 14-methoxymetopon (13) in various models of pain in rodents.
| Pain model | Route | ED50 | Potency versus morphine | Reference |
| Hot-plate test (mouse) | | | | | 50°C | s.c. | 54 μg/kg | 24 | [29] | 52°C | s.c. | 28 μg/kg | 94 | [14] | 56°C | s.c. | 30 μg/kg | 28 | [30] |
| Hot-plate test 55°C (rat) | s.c. | 15 μg/kg | 313 | [25] |
| | s.c. | 30 μg/kg | 63 | [30] | | s.c. | 28 μg/kg | 82 | [14] | Tail-flick test (mouse) | s.c. | 7.6 μg/kg | 500 | [31] | | i.c.v. | 0.29 fg/animal | >1,000,000 | [31] | | i.t. | 0.31 fg/animal | >1,000,000 | [31] |
| Tail-flick test (rat) | s.c. | 7.2 μg/kg | 250 | [25] | | i.p. | 40 μg/kg | 125 | [25] |
| Tail electric stimulation test (rat) | s.c. | 30 μg/kga | 167 | [33] |
| Writhing test (mouse) | | | | | acetic acid | s.c. | 7 μg/kg | 99 | [25] | PPQ | s.c. | 9 μg/kg | 44 | [30] |
| Carrageenan-induced inflammatory pain (rat) | s.c. | 20 μg/kga | 100 | [35] |
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aSignificant effect.
|