Synthesis and Anticonvulsant Activity of Various Mannich and Schiff Bases of 1,5-Benzodiazepines

Table 1

Physicochemical data of synthesized compounds.

Compound code	Molecular formula	Molecular weight	Melting point (°C)	% yield	Rf value	Log 𝑃 value
NBZD-1	C18H24N	268.19	110	76.48	0.689	4.25
NBZD-3	C 27H32N2O	400.25	92	85.7	0.78	6.25
NBZD-4	C33H36N3Cl	510.12	132	83.3	0.73	6.15
NBZD-5	C34H28ClN5O	568.15	140	72	0.83	6.81
NBZD-6	C27H31N3O3	445.55	98	84.3	0.63	8.93
NBZD-7	C27H31ClN2O	435.00	98	79.2	0.82	6.70
NBZD-8	C33H35ClN4O2	554.24	130	67.2	0.57	9.49
NBZD-9	C34H37ClN6O3	612.26	126	56.98	0.52	8.07
NBZD-10	C33H35Cl2N3	543.22	136	65.8	0.54	9.56
NBZD-11	C34H37Cl2N5O	601.24	130	66	0.66	8.62
NBZD-12	C12H16N2	188.60	96	72	0.68	2.22
NBZD-13	C21H24N2O	320.3	98	72.32	0.72	4.22
NBZD-14	C21H23N3O3	365.43	102	92.1	0.72	4.83
NBZD-15	C21H24N2O	320.43	110	57.6	0.75	4.78
NBZD-16	C21H23ClN2O	354.87	108	82.9	0.73	6.90
NBZD-17	C27H28ClN3	429.98	140	90.4	0.78	7.20
NBZD-18	C27H27ClN4O2	474.98	136	64.06	0.75	7.46
NBZD-19	C27H27Cl2N3	464.43	142	85.6	0.63	6.04
NBZD-20	C27H27ClN4O2	474.18	138	67.9	0.55	—
NBZD-21	C28H29ClN6O3	532.20	142	65.2	0.76	6.59

Rf value: solvent system; chloroform : methanol 1 : 1.