International Journal of Medicinal Chemistry / 2012 / Article / Tab 1

Research Article

Synthesis and Anticonvulsant Activity of Various Mannich and Schiff Bases of 1,5-Benzodiazepines

Table 1

Physicochemical data of synthesized compounds.

Compound codeMolecular formulaMolecular weightMelting point (°C)% yieldRf valueLog value

NBZD-1C18H24N 268.1911076.480.6894.25
NBZD-3C 27H32N2O 400.259285.70.786.25
NBZD-4C33H36N3Cl 510.1213283.30.736.15
NBZD-5C34H28ClN5O 568.15140720.836.81
NBZD-6C27H31N3O3 445.559884.30.638.93
NBZD-7C27H31ClN2O 435.009879.20.826.70
NBZD-8C33H35ClN4O2554.2413067.20.579.49
NBZD-9C34H37ClN6O3612.2612656.980.528.07
NBZD-10C33H35Cl2N3543.2213665.80.549.56
NBZD-11C34H37Cl2N5O 601.24130660.668.62
NBZD-12C12H16N2188.6096720.682.22
NBZD-13C21H24N2O 320.398 72.32 0.724.22
NBZD-14C21H23N3O3365.4310292.10.724.83
NBZD-15C21H24N2O 320.4311057.60.754.78
NBZD-16C21H23ClN2O 354.8710882.90.736.90
NBZD-17C27H28ClN3429.9814090.40.787.20
NBZD-18C27H27ClN4O2474.9813664.060.757.46
NBZD-19C27H27Cl2N3464.4314285.60.636.04
NBZD-20C27H27ClN4O2474.1813867.90.55
NBZD-21C28H29ClN6O3532.2014265.20.766.59

Rf value: solvent system; chloroform : methanol 1 : 1.

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