Research Article

Synthesis and Anticonvulsant Activity of Various Mannich and Schiff Bases of 1,5-Benzodiazepines

Table 3

Anticonvulsant activity using Isoniazid induced convulsion model.

Compound code Isoniazid induced modelNeurotoxicity study
0.5 hr1 hr2 hr1 hr4 hr
Dose: 30 mg/kg

NBZD-1 30 mg 30 mgNot protectedNNNN
NBZD-330 mg30 mg30 mgNNNN
NBZD-430 mgNot protectedNot protectedNNNN
NBZD-530 mgNot protectedNot protectedNNNN
NBZD-630 mg30 mgNot protectedNNNN
NBZD-730 mgNot protectedNot protectedNNNN
NBZD-830 mg30 mg30 mgNNNN
NBZD-930 mgNot protectedNot protectedNNNN
NBZD-1030 mg30 mgNot protectedNNNN
NBZD-1130 mg30 mgNot protectedNNNN

Symbol (NN) indicates no neurotoxicity at 30 mg/kg b.w.