Synthesis and Anticonvulsant Activity of Various Mannich and Schiff Bases of 1,5-Benzodiazepines

Table 3

Anticonvulsant activity using Isoniazid induced convulsion model.

Compound code	Isoniazid induced model			Neurotoxicity study
	0.5 hr	1 hr	2 hr	1 hr	4 hr
				Dose: 30 mg/kg
NBZD-1	30 mg	30 mg	Not protected	NN	NN
NBZD-3	30 mg	30 mg	30 mg	NN	NN
NBZD-4	30 mg	Not protected	Not protected	NN	NN
NBZD-5	30 mg	Not protected	Not protected	NN	NN
NBZD-6	30 mg	30 mg	Not protected	NN	NN
NBZD-7	30 mg	Not protected	Not protected	NN	NN
NBZD-8	30 mg	30 mg	30 mg	NN	NN
NBZD-9	30 mg	Not protected	Not protected	NN	NN
NBZD-10	30 mg	30 mg	Not protected	NN	NN
NBZD-11	30 mg	30 mg	Not protected	NN	NN
Control	—	—	—

Symbol (NN) indicates no neurotoxicity at 30 mg/kg b.w.