Research Article
Synthesis and Anticonvulsant Activity of Various Mannich and Schiff Bases of 1,5-Benzodiazepines
Table 4
Anticonvulsant activity using thiosemicarbazide induced convulsion model.
| Compound code | Thiosemicarbazide induced model | Neurotoxicity study | 0.5 hr | 1 hr | 2 hr | 1 hr | 4 hr | | | | Dose: 30 mg/kg |
| NBZD-12 | 30 mg | 30 mg | Not protected | NN | NN | NBZD-13 | 30 mg | 30 mg | 30 mg | NN | NN | NBZD-14 | 30 mg | Not protected | Not protected | NN | NN | NBZD-15 | 30 mg | Not protected | Not protected | NN | NN | NBZD-16 | 30 mg | 30 mg | Not protected | NN | NN | NBZD-17 | 30 mg | Not protected | Not protected | NN | NN | NBZD-18 | 30 mg | 30 mg | 30 mg | NN | NN | NBZD-19 | 30 mg | Not protected | Not protected | NN | NN | NBZD-20 | 30 mg | Not protected | Not protected | NN | NN | NBZD-21 | 30 mg | 30 mg | Not protected | NN | NN | Control | — | — | — | | |
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Symbol (NN) indicates no neurotoxicity 30 mg/kg of b.w.
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