Synthesis and Anticonvulsant Activity of Various Mannich and Schiff Bases of 1,5-Benzodiazepines

Table 5

Sedative activity of synthesized compound.

Compounds code	Sleeping time (mean ± SEM); (min)
NBZD-1	120 ± 9.00**
NBZD-3	138 ± 10.53**
NBZD-4	140 ± 11.92**
NBZD-7	141 ± 11.21**
NBZD-8	68 ± 12.6 NS
NBZD-10	63 ± 9.05 NS
NBZD-11	148 ± 12.15**
NBZD-12	124 ± 10.12**
NBZD-14	110 ± 11.41 **
NBZD-15	100 ± 10.98**
NBZD-17	148 ± 11.54**
NBZD-18	76 ± 10.26 NS
NBZD-20	112 ± 9.62**
NBZD-21	157 ± 12.09**
Phenobarbitone (control )	56 ± 11.47

Values represent the mean ± SEM of six animals for each group.
^*Significant at 𝑃<0.05 and **significant at 𝑃<0.01 (Dunnett’s test).
Test drug (30 mg/kg) and Phenobarbitone (40 mg/kg).
NS denotes not significant at 𝑃<0.01 (student’s 𝑡-test).