International Journal of Medicinal Chemistry / 2012 / Article / Tab 5

Research Article

Synthesis and Anticonvulsant Activity of Various Mannich and Schiff Bases of 1,5-Benzodiazepines

Table 5

Sedative activity of synthesized compound.

Compounds codeSleeping time (mean ± SEM)
(min)

NBZD-1 120 ± 9.00**
NBZD-3 138 ± 10.53**
NBZD-4 140 ± 11.92**
NBZD-7 141 ± 11.21**
NBZD-8 68 ± 12.6 NS
NBZD-1063 ± 9.05 NS
NBZD-11 148 ± 12.15**
NBZD-12 124 ± 10.12**
NBZD-14 110 ± 11.41 **
NBZD-15 100 ± 10.98**
NBZD-17 148 ± 11.54**
NBZD-18 76 ± 10.26 NS
NBZD-20 112 ± 9.62**
NBZD-21 157 ± 12.09**
Phenobarbitone (control ) 56 ± 11.47

Values represent the mean ± SEM of six animals for each group.
*Significant at and **significant at (Dunnett’s test).
Test drug (30 mg/kg) and Phenobarbitone (40 mg/kg).
NS denotes not significant at (student’s -test).

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