Research Article

In Silico Inhibition Studies of Jun-Fos-DNA Complex Formation by Curcumin Derivatives

Figure 6

Binding modes of other known inhibitors. (a) T5224 (blue), dihydroguaiaretic acid (green), and resveratrol (cyan) docked to DBR of Jun-Fos complex (b) T5224 (cyan) showing polar contacts with Arg158, Asn271, Ser278, Arg279, and Lys282 (magenta); (c) Dihydroguaiaretic acid (cyan) showing polar contacts with Ser278 and Arg279 (magenta); (d) resveratrol (cyan) showing polar contacts with Ser154 and Lys282 (magenta).
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(a)
316972.fig.006b
(b)
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(c)
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(d)