MDAN-21: A Bivalent Opioid Ligand Containing mu-Agonist and Delta-Antagonist Pharmacophores and Its Effects in Rhesus Monkeys
Figure 2
Effects of MDAN-21, morphine, and vehicle in morphine-dependent monkeys in spontaneous withdrawal. aSignificantly less () than vehicle and 0.001 mg/kg of MDAN-21. bSignificantly less () than MDAN-21. Each point shows mean ± S.E.M. from at least 4 monkeys.