International Journal of Medicinal Chemistry / 2012 / Article / Fig 3

Research Article

Pharmacophore Modelling and 3D-QSAR Studies on N πŸ‘ -Phenylpyrazinones as Corticotropin-Releasing Factor 1 Receptor Antagonists

Figure 3

Best pharmacophore model AADHHR.47 aligned with molecule 48. Pharmacophore features are color coded: 2 hydrogen bond acceptors (A2, A4; pink), 1 hydrogen bond donor (D6; blue), 2 hydrophobic regions (H10, H11; green), and 1 aromatic ring (R12; orange).

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