A DFT and Semiempirical Model-Based Study of Opioid Receptor Affinity and Selectivity in a Group of Molecules with a Morphine Structural Core

Table 13

Beta coefficients and 𝑡-test for significance of coefficients in (21).

Variable	Beta coefficient	𝑡	𝑃
𝜔15	0.44	4.15	<0.0008
𝑆^𝑁11	0.51	6.34	<0.002
𝑆^𝐸1(HOMO−1)	−0.47	−4.51	<0.00006
𝐹11(LUMO)	−0.30	3.63	<0.004