A DFT and Semiempirical Model-Based Study of Opioid Receptor Affinity and Selectivity in a Group of Molecules with a Morphine Structural Core

Table 2

Beta coefficients and 𝑡-test for significance of coefficients in (17).

Variable	Beta coefficient	𝑡	𝑃
𝑆^𝑁3(LUMO+1)	0.24	3.93	<0.0023
𝜂6	−0.84	−14.39	<0.000001
𝑄13	0.32	4.94	<0.0004
𝑆^𝑁13(LUMO+2)	0.31	5.16	<0.0003