International Journal of Medicinal Chemistry / 2012 / Article / Tab 1

Research Article

Syntheses and In Vitro Biological Activity of Some Derivatives of C-9154 Antibiotic

Table 1

Synthesized C-9154 analogue and its derivatives.

Sample codeTypeYield (mg)Melting point (°C)Physical State

IA/12/1C-9154 analogue91.7%125–127Shiny white crystalline solid
IA/27/1/BMethyl ester140,
(0.64 mmol)
not determinedColourless oil
IA/28/1/BEthyl ester105,
(0.45 mmol)
79Light yellow crystalline solid
IA/29/1/B*n-propyl ester170,
(0.69 mmol)
40White crystalline solid
IA/30/1/B*Isopropyl ester185,
(0.75 mmol)
67White crystalline solid
IA/31/1/B*n-butyl ester100,
(0.38 mmol)
not determinedColourless oil
IA/32/1/B*2-butyl ester125,
(0.48 mmol)
not determinedColourless oil

*Synthesized for the first time. Confirmed from available data and on Scifinder.

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